55582-10-0Relevant academic research and scientific papers
Synthesis of (+)-Lentiginosine and Its Pyrrolizidine Analogue Based on Intramolecular Cyclization of α-Sulfinyl Carbanions
Du-A-Man, Sakkarin,Soorukram, Darunee,Kuhakarn, Chutima,Tuchinda, Patoomratana,Reutrakul, Vichai,Pohmakotr, Manat
, p. 1708 - 1715 (2014)
A synthesis of (+)-lentiginosine and its pyrrolizidine analogue was accomplished in six steps, starting from L-(+)-tartaric acid. The key step of these syntheses involves the intramolecular cyclization of α-sulfinyl carbanions for the construction of the indolizidine or pyrrolizidine ring.
SUBSTITUTED BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS
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, (2015/12/31)
The present invention relates to substituted benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides substituted benzoxazolone derivatives for use in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents
Hu, Kun,Qi, Yan-Jie,Zhao, Juan,Jiang, He-Fei,Chen, Xin,Ren, Jie
, p. 529 - 539 (2013/07/11)
A series of sulforaphane derivatives were synthesized and evaluated in vitro for their cytotoxicity against five cancer cell lines (HepG2, A549, MCF-7, HCT-116 and SH-SY5Y). The pharmacological results showed that many of the derivatives displayed more potent cytotoxicity than sulforaphane (SFN). Furthermore, SFN and derivative 85 could induce cell cycle arrest at S or G2/M phase and cell apoptosis. SFN and 85 exhibited time- and dose-dependent activation on Nrf2 transcription factor, and 85 acted as a more potent Nrf2 inducer than SFN.
Synthesis, spectral studies and C-S, C-N bond fissions of some novel N-[alkyl (4′-substituted phenylthio)] phthalimides
El-Bardan, Ali A.
, p. 511 - 519 (2007/10/03)
N-[(4′-Substituted phenylthio)ethyl] phthalimide la-g and their corresponding n-propyl 2a-g, n-butyl 3a-g derivatives have been synthesised. The structure of these compounds were proved by UV, IR, 1H NMR, 13CMR and mass spectra. The 1H and 13C chemical shifts of the adjacent methylene protons and carbons of both the sulfur atom and phthalimido nitrogen group were reasonably correlated using σ° values. The carbon-nitrogen and the carbon-sulfur bond fissions in alkaline and acidic media were discussed.
Photochemistry of the Phthalimide System, 37. - Thiazacycloalkanols by Photocyclization of S-Substituted N-(Thioalkyl)phthalimides
Sato, Yasuhiko,Nakai, Hideo,Wada, Masao,Mizoguchi, Tomishige,Hatanaka, Yasumaru,et al.
, p. 1099 - 1118 (2007/10/02)
N-Substituted phthalimides (1,2) possessing a terminal thioether function in their side chain were irradiated with a high-pressure mercury lamp to give a variety of thiazacycloalkanol derivatives (3,7,9-13,16,17) with favored γ-, δ-, ε-, and ζ-hydrogen abstractions (Table 1), in moderate to fairly good yields.
