13565-42-9

Upstream product

• 39096-24-7 3-chlorocinnamoyl chloride 
• 108-88-3 toluene 
• 587-04-2 m-Chlorobenzaldehyde 
• 122-00-9 para-methylacetophenone 
• 5142-75-6 tri(p-tolyl)bismuth 
• 2039-85-2 3-Chlorostyrene 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 

Downstream Products

• 649739-73-1 2,3-dibromo-3-(3-chloro-phenyl)-1-p-tolyl-propan-1-one 
• 1878-65-5 3-chlorophenylacetic acid 
• 99-94-5 p-Toluic acid 
• 1204687-43-3 C₂₈H₂₃ClN₄ 
• 84857-15-8 4-(3-Chloro-phenyl)-6-p-tolyl-pyrimidin-2-ylamine 
• 1374585-14-4 4-(3-chlorophenyl)-6-p-tolyl-2,2'-bipyridine 
• 1616723-64-8 (E)-N-(1-(m-chlorophenyl)-3-(p-tolyl)allyl)-4-methylbenzenesulfonamide 
• 1622272-20-1 (E)-N-(3-(m-chlorophenyl)-1-(p-tolyl)allyl)-4-methylbenzenesulfonamide 
• 1616723-38-6 (E)-3-(3-chlorophenyl)-1-(p-tolyl)prop-2-en-1-ol 

Relevant academic research and scientific papers

1, 2, 4-triazoles clubbed pyrimidine compounds with synthesis, antimicrobial, antituberculosis, antimalarial, and anti-protozoal studies

Triazoles are famous as an antifungal agent. Itraconazole and fluconazole are the best examples of antifungal drugs available in the market, which consist of an active triazole moiety. Pyrimidines are also bioactive molecules which shows multiple bioactivity. It’s an effort to synthesize pyrimidine clubbed triazole to enhance bioactivity. To synthesize new active pyrimidine clubbed triazole biomolecule and to evaluate these new products for better drug potential as antimicrobial, antituberculosis, antimalarial, and anti-protozoal, N-[4-(substituted phenyl)-6-(substituted aryl) pyrimidine-2-yl]-2-[(4H-1,2,4-triazol-4-yl)amino]acetamide(3A-J) were synthesized by different method such as cyclization, condensation, purification and crystallization. The newly synthesized compounds were characterized by IR,1H NMR,13C NMR and mass spectral analysis and screened for antibacterial, antifungal, anti-tuberculosis, antimalarial, and antiprotozoal activities. These compounds satisfied the bioactive response and simple way for the synthesis.

Lewis acid catalyst system for Claisen-Schmidt reaction under solvent free condition

Ca(OTf)2 in combination with NBu4.BF4 was established to function as an efficient catalyst system for one-pot Claisen-Schmidt condensation under neat conditions. Substituted acetophenones and benzaldehydes were coupled in situ to afford their corresponding chalcones in excellent yields. The method, with a broad range of substrate tolerance and mild operational conditions can produce assorted chalcone derivatives in moderate to high yields from easily accessible starting materials.

Domino-Fluorination-Protodefluorination Enables Decarboxylative Cross-Coupling of α-Oxocarboxylic Acids with Styrene via Photoredox Catalysis

Domino-fluorination-protodefluorination decarboxylative cross-coupling of α-keto acids with styrene has been developed via photoredox catalysis. The critical part of this strategy is the formation of the carbon-fluorine (C-F) bond by the capture of a carbon-centered radical intermediate, which will overcome side reactions during the styrene radical functionalization process. Experimental studies have provided evidence indicating a domino-fluorination-protodefluorination pathway with α-keto acid initiating the photoredox cycle. The present catalytic protocol also affords a novel approach for the construction of α,β-unsaturated ketones under mild conditions.

Preparation method of alpha-beta-unsaturated carbonyl compound

The invention relates to a preparation method of an alpha-beta-unsaturated carbonyl compound, in particular to a method in which the alpha-beta-unsaturated carbonyl compound is prepared from substitute propargyl alcohol in a mode that positive ion modified imvite serves as a catalyst, the substitute propargyl alcohol serves as the raw material, and Meyer-Schuster rearrangement is utilized. According to the method, the substrate is wide in application range, the catalyst is cheap, easy to manufacture, stable, free of pollution to the environment and capable of being recycled, the reaction yield is high, stereoselectivity is good, and an E-type product can be obtained in a singular mode.

Catalyzed Claisen-Schmidt reaction by protonated aluminate mesoporous silica nanomaterial focused on the (E)-chalcone synthesis as a biologically active compound

The mesoporous silica structure (MSN) was synthesized using the sol-gel method followed by aluminum grafting and protonation and was then denoted as HAlMSN (Si/Al = 18.9). N2 physisorption confirmed the mesoporous structure with a pore diameter of 3.38 nm. 27Al NMR showed the presence of framework and extra-framework aluminum structures, which led to the formation of strong Lewis and Br?nsted acidic sites. HAlMSN catalyzed the synthesis of (E)-chalcones through the Claisen-Schmidt reaction. Chalcone derivatives have been applied as biologically active compounds with anti-cancer, anti-inflammatory and diuretic pharmacological activities. The products were obtained via reactions on the protonic acid sites of HAlMSN. The significant advantages of this reaction are high yield, easy work up, short reaction time and also compatibility with various organic solvents. The products were obtained in an excellent conversion of 97% at 298 K. The results show that the electron donating substituents exhibit higher conversion in comparison to electron withdrawing substituents. The stability of the catalyst was investigated by reusing it five times for (E)-chalcone production and there was only a slight decrease in its catalytic activity. The highest product of (E)-chalcone was observed with a 1:2 molar ratio of benzaldehyde/acetophenone. A comparative study in chalcone synthesis using the heterogeneous catalysts demonstrated that HAlMSN has a significantly high activity at low temperature.

Synthesis of 1,3,5-trisubstituted pyrazoline derivatives and their applications

A series of 1,3,5-trisubstituted pyrazolines based homoleptic Ru(iii) complexes of type [Ru(L1-7)3]·(PF6)3 (L1-7 = pyrazoline ligands) have been synthesized and characterized by elemental analysis, el

Synthesis, spectral investigation and biological interphase of drug-based cytotoxic square pyramidal coordination compounds

We have synthesized ciprofloxacin-based metal complexes of bipyridine derivatives [Cu(CFL)(An)Cl].2H2O (where CFL=ciprofloxacin and A=bipyridines e.g. A1=4-(4-fluorophenyl)-6-p-tolyl-2,2′- bipyridine, A6=4-(4-(b

A palladium catalyzed atom-efficient cross-coupling reactivity of triarylbismuths with α,β-unsaturated acyl chlorides

An atom-efficient cross-coupling reactivity of triarylbismuths (1 equiv) was demonstrated by cross-coupling reaction with 3 equiv of α,β-unsaturated acyl chlorides under palladium catalysis in the synthesis of a series of functionalized α, β-unsaturated ketones in high isolated yields.

Synthesis of some new cyanopyrans and cyanopyridines and their biological activities

Chalcones 1-aryl-3-m-chlorophenyl-2-propene-1-ones, 1a-j, underwent Michael addition on refluxing with malononitrile in the presence of pyridine and ammonium acetate in ethanol to give compounds 2-amino-3-cyano-4-(3′ -chlorophenyl),6-(4-phenyl)-pyran, 2a-

Synthesis and biological activity of 3-aryl-5-(3′ -bromo/chlorophenyl)isoxazoles

3-Aryl-5-(3′-bromo/chlorophenyl)isoxazole derivatives (3a-j, 4a-j) have been prepared by condensing 1-aryl-3-(3′-bromo/ chlorophenyl)-2-propen-1-ones (1a-j, 2a-j) with hydroxylamine hydrochloride. Compounds 1a-j, 2a-j have been synthesized by the reaction