1356550-80-5Relevant academic research and scientific papers
Antiproliferative activity of Pt(IV) complexes with lonidamine and bexarotene ligands attached via succinate-ethylenediamine linker
Okulova,Zenin,Shutkov,Kirsanov,Kovaleva,Lesovaya,Fetisov,Milaeva,Nazarov
, (2019)
We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with lonidamine and bexarotene ligand tethered to Pt-center via a succinate-ethylenediamine linker. The in vitro results for a series of complexes with cisplatin, dichloride(ethane-1,2-diamine)platinum(II), or oxaliplatin core indicate that the addition to the structure lonidamine or bexarotene moiety can confer activity or selectivity of Pt(IV) complexes.
Synthesis and biological evaluation of novel AM80 derivatives as antileukemic agents
Bian, Haiyong,Feng, Jinhong,Xu, Wenfang
, p. 175 - 185 (2013/03/13)
A series of novel AM80 derivatives as antileukemic agents were synthesized and their structures were confirmed by IR, 1H-NMR, and HR-MS spectra. All the target compounds were evaluated for in vitro antiproliferative activities against human leukemic HL-60, NB4, and K562 cell lines. Among these derivatives, compound 4g showed much stronger antiproliferative activities against all the three human leukemic cell lines than the positive control AM80, and compound 4b exhibited more active antiproliferative effects against HL-60 and K562 cells than AM80. Furthermore, the preliminary SAR analysis suggested that AM80 conjugating with HDAC inhibitors with small steric hindrance could give more effective antileukemic agents. These results would be helpful to design more potent antileukemic drugs for the treatment of human leukemia.
