135659-89-1Relevant academic research and scientific papers
Formal [4 + 1] Annulation of α-Arylhydrazonoketones and Dimethylsulfoxonium Methylide: One-pot Synthesis of Substituted Pyrazoles and Dihydropyrazoles
Zhang, Qian,Yu, Mangfei,Yuan, Jingwen,Zhang, Rui,Liang, Yongjiu,Tian, Jiamei,Dong, Dewen
, p. 6036 - 6041 (2016/07/26)
A formal [4 + 1] annulation of readily available α-arylhydrazonoketones and trimethylsulfoxonium iodide in the presence of cesium carbonate is described involving a sequential Corey-Chaykovsky reaction and intramolecular nucleophilic cyclization process. Substituted pyrazoles were obtained exclusively from the reactions of α-arylhydrazono-β-oxo-amides and trimethylsulfoxonium iodide in moderate to good yields, whereas the reactions of α-arylhydrazono-β-oxo-ketone/α-arylhydrazono- β-oxo-ester afforded the corresponding dihydropyrazoles in good yields.
