14766-43-9

Basic information

• Product Name: 1-Phenyl-4-methylpyrazole
• Synonyms: 1-Phenyl-4-methylpyrazole;4-methyl-1-phenyl-1H-Pyrazole
• CAS NO: 14766-43-9
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.2
• Mol File: 14766-43-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 262.9 °C at 760 mmHg
• Flash Point: 112.8 °C
• Appearance: /
• Density: 1.04g/cm³
• Vapor Pressure: 0.0173mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: 1-Phenyl-4-methylpyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-4-methylpyrazole(14766-43-9)
• EPA Substance Registry System: 1-Phenyl-4-methylpyrazole(14766-43-9)

Safety Data

• Hazardous Substances Data: 14766-43-9(Hazardous Substances Data)

Usage

General Description

1-Phenyl-4-methylpyrazole is a chemical compound with the molecular formula C10H12N2. It is a pyrazole derivative with a phenyl group and a methyl group attached to the pyrazole ring. 1-Phenyl-4-methylpyrazole has been studied for its potential pharmacological properties, including its ability to inhibit the enzyme aromatase, which is involved in the synthesis of estrogen. 1-Phenyl-4-methylpyrazole has also been investigated for its potential use in the treatment of cancer, particularly hormone-dependent cancers. Additionally, it has been studied as a potential ingredient in sunscreen formulations due to its ability to absorb ultraviolet radiation. Overall, 1-Phenyl-4-methylpyrazole has shown promise in various pharmacological and medical applications and continues to be a subject of research.

InChI:InChI=1/C10H10N2/c1-9-7-11-12(8-9)10-5-3-2-4-6-10/h2-8H,1H3

Upstream product

• 241798-67-4 4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid 
• 98958-40-8 3-ethoxy-2-ethoxymethyl-3-methoxy-propylamine 
• 100-63-0 phenylhydrazine 
• 123-38-6 propionaldehyde 
• 508191-77-3 3-phenylsydnone 
• 7554-65-6 4-methyl-1H-pyrazole 
• 71-43-2 benzene 
• 39567-92-5 1,1,3,3-tetramethoxy-2-methyl-propane 
• 70583-58-3 1-acetyl-4-methyl-1H-pyrazole 
• 98-80-6 phenylboronic acid 
• 62-53-3 aniline 
• 1126-00-7 1-phenylpyrazole 
• 102017-38-9 1-(4-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-ethanone phenylhydrazone 
• 135659-89-1 1-(4-methyl-1-phenyl-1H-pyrazol-3-yl)ethanone 

Downstream Products

• 1621514-53-1 1-(2-allylphenyl)-4-methyl-1H-pyrazole 
• 806632-06-4 4-(4-methyl-1H-pyrazol-1-yl)aniline 
• 150587-23-8 (E)-2-methyl-3-(N-phenylamino)propenenitrile 
• 13808-73-6 4-methyl-1-(4-nitrophenyl)-1H-pyrazole 
• 1134-50-5 4-carboxy-1-phenylpyrazole 

Relevant articles and documents

New Pt(II) complex with extra pure green emission for OLED application: synthesis, crystal structure and spectral properties

New (2-(4-methylpyrazol-1-yl)phenyl) platinum(II) (dibenzoylmethane) Pt(mpp)(dbm) complex based on 4-methylpyrazole was synthesized using a simple scheme. Its crystal structure, spectral and electrochemical properties were studied. The extra pure green (CIE chromacity coordinates X = 0.1419, Y = 0.7444) electroluminescence for OLED structures was obtained.

Unveiling Potent Photooxidation Behavior of Catalytic Photoreductants

We describe a photocatalytic system that reveals latent photooxidant behavior from one of the most reducing conventional photoredox catalysts, N-phenylphenothiazine (PTH). This aerobic photochemical reaction engages difficult to oxidize feedstocks, such as benzene, in C(sp2)-N coupling reactions through direct oxidation. Mechanistic studies are consistent with activation of PTH via photooxidation and with Lewis acid cocatalysts scavenging inhibitors inextricably formed in this process.

Copper-catalyzed C–N cross-coupling of arylboronic acids with N-acylpyrazoles

A copper-catalyzed C–N bond forming reaction of arylboronic acids and N-acylpyrazoles was developed. This procedure used N-acetyl protected pyrazoles as starting material instead of free pyrazoles (NH). The reaction worked under neutral conditions and did not require any base or ligand. The reaction showed good functional group tolerance.