7563-03-3

Upstream product

• 37941-54-1 α,ε-Dicarbobenzoxy-L-lysyl-glycine 
• 90970-53-9 Z-L-Lys(Z)-Gly-OBzl 
• 24733-49-1 α-Z,ε-Pipoc-Lys-Gly-OPic 
• 40719-48-0 N-[(S)-2-benzyloxycarbonylamino-6-(2-oxo-4,5-diphenyl-oxazol-3-yl)-hexanoyl]-glycine ethyl ester 
• 56-87-1 L-lysine 
• 56-40-6 glycine 
• 623-33-6 glycine ethyl ester hydrochloride 
• 13567-34-5 N_α,N_ξ-di-Cbz-L-lysylglycine ethyl ester 
• 405-39-0 N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine 
• 2212-75-1 N₂-[(benzyloxy)carbonyl]-L-lysine 
• 40719-44-6 (S)-2-benzyloxycarbonylamino-6-(2-oxo-4,5-diphenyl-oxazol-3-yl)-hexanoic acid; dicyclohexylamine salt 

Relevant academic research and scientific papers

Prolonged delivery of peptides

There are disclosed methods for the treatment of non-insulin dependent diabetes mellitus in a mammal comprising the prolonged administration of GLP-1 (7-37), and related peptides. Also disclosed are compositions to prolong the administration of the peptides.

The Relationship between Taste and Primary Structure of "Delicious Peptide" (Lys-Gly-Asp-Glu-Glu-Ser-Leu-Ala) from Beef Soup

"Delicious peptide" was reported to be as delicious as beef soup.The peptide and its fragments were synthesized to study its taste active sites. "Delicious peptide" was found to produce a umami and a sour taste.By preparing several di- or tripeptides composed of basic or acidic amino acids, we found that the taste of "delicious peptide" was produced by an interaction between the basic and the acidic fragments in the peptide.

Process for producing triglycyl-lysine vasopressin and intermediates therefor

A new process for preparing the cyclic dodecapeptide triglycyl-lysine vasopressin of the formula STR1 which comprises the preparation of a first hexapeptide of formula Boc--Gly--Gly--Gly--Cys(Trt)--Tyr--Phe--NHNH2 and a second hexapeptide of formula H--Gln(Mbh)--Asn(Mbh)--Cys(Trt)--Pro--Lys(Boc)--Gly--NH2 by a series of condensations involving the reaction of an appropriately protected peptide unit having an activated carboxyl with an appropriately protected peptide having a free amino group. Subsequently, the first and second hexapeptides are condensed according to the azide coupling method to obtain the linear protected dodecapeptide of formula Boc--Gly--Gly--Gly--Cys(Trt)--Tyr--Phe--Gln(Mbh)--Asn(Mbh)--Cys(Trt)--Pro--Lys(Boc)--Gly--NH2 ; thereafter the linear protected dodecapeptide is transformed into the desired cyclic dodecapeptide, triglycyllysine vasopressin, by oxidizing and deprotecting processes.