1356928-62-5

Basic information

• Product Name: 7-p-methoxybenzyloxy-6-prenylcoumarin
• Synonyms: 7-p-methoxybenzyloxy-6-prenylcoumarin
• CAS NO: 1356928-62-5
• Molecular Weight: 350.414
• Mol File: 1356928-62-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-p-methoxybenzyloxy-6-prenylcoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 7-p-methoxybenzyloxy-6-prenylcoumarin(1356928-62-5)
• EPA Substance Registry System: 7-p-methoxybenzyloxy-6-prenylcoumarin(1356928-62-5)

Safety Data

• Hazardous Substances Data: 1356928-62-5(Hazardous Substances Data)

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 1356928-61-4 4-p-methoxybenzyloxy-o-prenyloxycinnamic acid methyl ester 
• 1356928-60-3 4-p-methoxybenzyloxy-o-hydroxycinnamic acid methyl ester 
• 374768-02-2 7-[(4-methoxybenzyl)oxy]-2H-chromen-2-one 
• 93-35-6 7-hydroxy-2H-chromen-2-one 

Downstream Products

• 1147-25-7 lomatin 
• 5993-18-0 decursinol 
• 5928-25-6 2,2-dimethyl-8-oxo-2,3,4,8-tetrahydropyrano[3,2-g]chromen-3-yl 3-methylbut-2-enoate 
• 495-32-9 marmesin 

Relevant articles and documents

Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor

The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins inhibited BACE1 activity, but simple coumarins and pyranocoumarins did not affect. The most potent inhibitor was 5-geranyloxy-8-methoxypsoralen (31), which has an IC50 value of 9.9 μM. Other furanocoumarin derivatives, for example, 8-geranyloxy-5- methoxypsoralen (35), 8-geranyloxypsoralen (24), and bergamottin (18) inhibited BACE1 activity, with the IC50 values 25.0 μM. Analyses of the inhibition mechanism by Dixon plots and Cornish-Bowden plots showed that compounds 18, 31 and 35 were mixed-type inhibitor. The kinetics of inhibition of BACE1 by coumarins 24 was non-competitive inhibitors.