374768-02-2

Basic information

• Product Name: 7-[(4-methoxyphenyl)methoxy]chromen-2-one
• Synonyms: 7-[(4-methoxyphenyl)methoxy]chromen-2-one
• CAS NO: 374768-02-2
• Molecular Formula: C₁₇H₁₄O₄
• Molecular Weight: 282.29066
• Mol File: 374768-02-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-[(4-methoxyphenyl)methoxy]chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-[(4-methoxyphenyl)methoxy]chromen-2-one(374768-02-2)
• EPA Substance Registry System: 7-[(4-methoxyphenyl)methoxy]chromen-2-one(374768-02-2)

Safety Data

• Hazardous Substances Data: 374768-02-2(Hazardous Substances Data)

Upstream product

• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 2746-25-0 p-Methoxybenzyl bromide 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1147-25-7 lomatin 
• 5993-18-0 decursinol 
• 5928-25-6 2,2-dimethyl-8-oxo-2,3,4,8-tetrahydropyrano[3,2-g]chromen-3-yl 3-methylbut-2-enoate 
• 1356928-61-4 4-p-methoxybenzyloxy-o-prenyloxycinnamic acid methyl ester 
• 1356928-62-5 7-p-methoxybenzyloxy-6-prenylcoumarin 
• 495-32-9 marmesin 
• 1356928-60-3 4-p-methoxybenzyloxy-o-hydroxycinnamic acid methyl ester 
• 1417997-42-2 C₁₉H₂₀O₅ 
• 1417997-48-8 C₂₀H₂₂O₅ 
• 1417997-54-6 C₁₈H₁₈O₅ 

Relevant articles and documents

Synthesis and bioactivity of novel coumarin derivatives

[Figure not available: see fulltext.] A series of novel coumarin derivatives were synthesized from commercially available chemical agents. All prepared compounds were evaluated for their in vitro antiproliferative activity against five selected human cancer cell lines (EC109, MGC-803, PC-3, MCF-7, and EC9706) and their in vitro antimicrobial activity against E. coli and M. albicans. 4-(3-Bromopropoxy)-2H-chromen-2-one exhibited the highest growth inhibition against MGC-803 cell line (IC50 47.7 μM) and 7-(2-bromoethoxy)-2H-chromen-2-one exhibited the highest growth inhibition against MCF-7 cell line (IC50 48.3 μM). The latter compound was also the most active against E. coli (MIC50 0.27 μg/ml).

Inhibitory effects of 6-alkoxycoumarin and 7-alkoxycoumarin derivatives on lipopolysaccharide/interferon γ-stimulated nitric oxide production in RAW264 cells

Coumarin and its derivatives are well known for their anti-inflammatory and anti-oxidative effects. In this study, we synthesized 32 coumarin derivatives from commercially available 6-hydroxycoumarin (6HC) and 7-hydroxycoumarin (7HC) and examined their ef