1357004-01-3

Upstream product

• 109-63-7 boron trifluoride diethyl etherate 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 625-82-1 2,4-dimethyl-1H-pyrrole 
• 455-19-6 4-Trifluoromethylbenzaldehyde 

Downstream Products

• 1189528-67-3 8-(4-trifluoromethylphenyl)-1,7-dimethyl-3,5-bis(4-methoxystyryl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene 
• 1357004-08-0 2,8-dibromo-5,5-difluoro-1,3,7,9-tetramethyl-10-(4-(trifluoromethyl)phenyl)-5H-dipyrrolo[1,2-c:2′,1′-f ][1,3,2]diazaborinin-4-ium-5-uide 
• 1357004-19-3 2-bromo-4,4-difluoro-1,3,5,7-tetramethyl-8-[4-(trifluoromethyl)phenyl]-4-bora-3a,4a-diaza-s-indacene 

Relevant academic research and scientific papers

Trifluoromethyl boron dipyrromethene derivatives as potential photosensitizers for photodynamic therapy

In this study, two novel boron dipyrromethene-based photosensitizers (BDP3 and BDP6) substituted with three or six trifluoromethyl groups have been synthesized and characterized with various spectroscopic methods, and their photo-physical, photo-chemical, and photo-biological properties have also been explored. The two photosensitizers are highly soluble and remain nonaggregated in N,N-dimethylformamide as shown by the intense and sharp Q-band absorption. Under red light irradiation (λ = 660 nm, 1.5 J/cm2), both photosensitizers show high and comparable cytotoxicity towards HepG2 human hepatocarcinoma and HeLa human cervical carcinoma cells with IC50 values of 0.42–0.49 μM. The high photocytotoxicity of BDP3 and BDP6 can be due to their high cellular uptake and low aggregation tendency in biological media, which result in a high efficiency to generate reactive oxygen species inside the cells. Confocal laser fluorescence microscopic studies indicate that they have superior selective affinities to the mitochondria and lysosomes of HepG2 and HeLa cells. The results show that these two trifluoromethyl boron dipyrromethene derivatives are potential anticancer agents for photodynamic therapy.

High Affinity Neutral Bodipy Fluorophores for Mitochondrial Tracking

We report the first high affinity neutral Bodipy fluorophores for selective imaging of mitochondria with notable sensitivity (～100 nM) and insignificant cytotoxicity even at very high concentration (～100 μM), when tested against HeLa cells. Further, these fluorophores are chemically robust and require no special conditions for storage.

Story of an Age-Old Reagent: An Electrophilic Chlorination of Arenes and Heterocycles by 1-Chloro-1,2-benziodoxol-3-one

By the use of 1-chloro-1,2-benziodoxol-3-one, an age-old reagent, the practical and efficient chlorination method is achieved. This hypervalent iodine reagent is amenable not only to the chlorination of nitrogen-containing heterocycles but also to selected classes of arenes, BODIPY dyes, and pharmaceuticals. In addition, the advantages, such as easy preparation and recyclable, air- and moisture-stable, in combination with the success in a gram-scale experiment grant this reagent great potential for industrial application.