1357024-84-0Relevant articles and documents
A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions
Huang, Guan-Jhong,Bhaskar Reddy, M. Vijaya,Kuo, Ping-Chung,Huang, Chieh-Hung,Shih, Hung-Cheng,Lee, E.-Jian,Yang, Mei-Lin,Leu, Yann-Lii,Wu, Tian-Shung
, p. 371 - 378 (2012)
In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.