52249-82-8

Upstream product

• 52249-81-7 4-benzyloxy-2-hydroxy-3,6-dimethoxybenzaldehyde 
• 77-78-1 dimethyl sulfate 
• 708-76-9 2-hydroxy-4,6-dimethoxybenzaldehyde 
• 1357024-84-0 2-(benzyloxy)-4,6-dimethoxyphenol 
• 54917-02-1 2-(benzyloxy)-4,6-dimethoxybenzaldehyde 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 3934-87-0 5-hydroxyvanillin 
• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 
• 29865-90-5 3-hydroxy-4,5-dimethoxybenzaldehyde 
• 57230-04-3 3,4-dimethoxy-5-benzyloxybenzaldehyde 
• 855242-15-8 1-(benzyloxy)-2,3,5-trimethoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 121-33-5 vanillin 
• 6274-74-4 2,6-dibenzyloxy-1,4-dimethoxybenzene 

Downstream Products

• 105827-25-6 4-benzyloxy-2'-hydroxy-2,3,4',5',6,6'-hexamethoxychalcone 
• 912957-28-9 Viscolin 
• 1357024-86-2 (E)-3-(4-(benzyloxy)-2,3,6-trimethoxyphenyl)-1-(4-(benzyloxy)-3-methoxyphenyl)-prop-2-en-1-one 
• 918549-42-5 1-Benzyloxy-4-[(Z)-3-(4-benzyloxy-3-methoxy-phenyl)-propenyl]-2,3,5-trimethoxy-benzene 

Relevant academic research and scientific papers

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent

Total synthesis of viscolin, an anti-inflammatory 1,3-diphenylpropane isolated from Viscum coloratum, employing the Wittig reaction is reported. Key steps in the synthesis of viscolin depend on the selection of protecting groups to maintain the para hydroxyl group that is the most critical chemical structure influencing the biological activity of viscolin and the utilization of microwave-assisted Wittig olefination reaction. Anti-inflammatory potency of the synthetic viscolin, its precursor product 16, and its analogue 17, through their effects on reactive oxygen species (ROS), nitric oxide (NO), and pro-inflammatory cytokine production in leukocytes and microglial cells were evaluated. Excellent inhibition of ROS and NO production in inflammatory cells could confer the synthetic viscolin to be a potent anti-inflammatory agent for the treatment of oxidative stress-induced diseases.