135715-84-3

Upstream product

• 937-14-4 3-chloro-benzenecarboperoxoic acid 

Downstream Products

• 139503-20-1 4-[5-fluoro-3-(3-ethoxycarbonylmethylthio-4-nitrophenylthio)phenyl]-4-methoxytetrahydropyran 
• 143128-42-1 4-[5-fluoro-3-(4-(4-hydroxybenzoyl)phenylthio)phenyl]-4-methoxytetrahydropyran 
• 135715-98-9 4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylthio)-5-fluorophenyl]-4-methoxytetrahydropyran 
• 139503-23-4 4-[5-fluoro-3-(3-(2-methoxycarbonylprop-2-yl)oxy-4-nitrophenylthio)phenyl]-4-methoxytetrahydropyran 
• 139487-02-8 4-[3-(1,3-dimethyl-2-oxo-2,3-dihydrobenzimidazol-5-ylthio)-5-fluorophenyl]-4-methoxytetrahydropyran 
• 139502-92-4 4-[5-fluoro-3-(4-methyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-7-ylthio)phenyl]-4-methoxytetrahydropyran 
• 143128-43-2 4-[3-(4-(4-tert-butoxycarbonylmethoxybenzyl)-phenylthio)-5-fluorophenyl]-4-methoxytetrahydropyran 
• 143128-58-9 4-[3-(4-(2-chloro-4-dimethylaminobenzyl)phenylthio)-5-fluorophenyl]-4-methoxytetrahydropyran 
• 161386-64-7 4'-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-α,α,α-trifluoroacetophenone 
• 151358-61-1 4'-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]acetophenone 
• 161386-38-5 5-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]indan-1-one 
• 151358-64-4 4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]benzaldehyde 
• 30186-18-6 4'-bromo-2'-hydroxyacetophenone 
• 35065-86-2 3-bromophenyl acetate 

Relevant academic research and scientific papers

5-lipoxygenase inhibitors quinoxalinyl derivatives

The invention concerns a heterocyclic derivative of the formula I STR1 wherein Q is an optionally substituted quinoxalinyl or a hydrogenated derivative thereof X1 is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms; R1 is (1-6C)alkyl, (3-6C)alkenyl or (3-6C)alkynyl; and R2 and R3 together form a group of the formula --A2 --X2 --A3 -- which, together with the carbon atom to which A2 and A3 are attached, defines a ring having 4 to 7 ring atoms, wherein A2 and A3, which may be the same or different, each is (1-4C)alkylene and X2 is oxy, thio, sulphinyl, sulphonyl or imino; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

5-LIPOXYGENASE INHIBITORS QUINOLINE OR ISOQUINOLINE DERIVATIVES

The invention concerns a heterocyclic derivative of the formula I wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; X1 is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms; R1 is (1-6C)alkyl, (3-6C)alkenyl or (3-6C)alkynyl; and R2 and R3 together form a group of the formula ?A2?X2?A3? which, together with the carbon atom to which A2 and A3 are attached, defines a ring having 4 to 7 ring atoms, wherein A2 and A3, which may be the same or different, each is (1-4C)alkylene and X2 is oxy, thio, sulphinyl, sulphonyl or imino; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase

SULPHONAMIDE DERIVATIVES

The invention concerns sulphonamide derivatives of the formula I wherein R1 includes (1-4C)alkyl; R2 and R3 together form ?A2 ?X2 ?A3? which defines a ring having 5 to 7 ring atoms, wherein A2 and A3 each is (1-3 C)alkylene and X2 is oxy, thio, sulphinyl or sulphonyl; A1 is a direct link to X1 or is (1-3 C)alkylene; X1 is oxy, thio, sulphinyl, sulphonyl or imino; Ar is optionally substituted phenylene or Ar is pyridylene; Q is nitrogen or of the formula CR7, wherein R7 includes hydrogen, halogeno, (1-4 C)alkyl and (1-4 C)alkoxy; each of R4 and R5 is (1-4 C)alkyl, (3-4 C)alkenyl, (3-4 C)alkynyl or optionally substituted phenyl, benzyl or pyridyl, or R5 may be hydrogen; and R6 has any of the meanings defined for R7; or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors

Heterocyclic derivatives

The invention concerns a heterocyclic derivative of the formula I wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms;, X1 is oxy, thio, sulphinyl, sulphonyl or imino;, Ar is phenylene which may optionally bear one or two substituents or, Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms;, R1 is (1-6C)alkyl, (3-6C)alkenyl or (3-6C)alkynyl; and, R2 and R3 together form a group of the formula -A2-X2-A3- which, together with the carbon atom to which A2 and A3 are attached, defines a ring having 4 to 7 ring atoms, wherein A2 and A3, which may be the same or different, each is (1-4C)alkylene and X2 is oxy, thio, sulphinyl, sulphonyl or imino;, or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.