1357293-53-8

Upstream product

• 109-04-6 2-bromo-pyridine 
• 367-12-4 2-fluorophenol 
• 4783-68-0 2-phenoxypyridine 

Downstream Products

• 1357292-96-6 2-{(3-fluoro-4'-methoxy-[1,1'-biphenyl]-2-yl)oxy}pyridine 
• 1357293-38-9 2-{[3-fluoro-4'-methoxy-(1,1'-biphenyl)-2-yl]oxy}-4-methylpyridine 
• 1357293-20-9 {3'-fluoro-2'-(pyridin-2-yloxy)[1,1'-biphenyl]-3-yl}(phenyl)methanone 
• 1357293-16-3 3'-fluoro-2'-(pyridin-2-yloxy)[1,1'-biphenyl]-4-yl 4-methylbenzenesulfonate 
• 1357293-15-2 {3'-fluoro-2'-(pyridin-2-yloxy)[1,1'-biphenyl]-4-yl}(phenyl)methanone 
• 1446517-21-0 (3-fluoro-2-(pyridin-2-yloxy)phenyl)(phenyl)methanone 
• 1446517-24-3 (3-fluoro-2-(pyridin-2-yloxy)phenyl)(2-methoxyphenyl)methanone 
• 1446517-25-4 methyl 4-(3-fluoro-2-(pyridin-2-yloxy)benzoyl)benzoate 
• 1446517-26-5 (3-fluoro-2-(pyridin-2-yloxy)phenyl)(4-(trifluoromethyl)phenyl)methanone 
• 1446517-27-6 (3-fluoro-2-(pyridin-2-yloxy)phenyl)(4-fluorophenyl)methanone 
• 1446517-28-7 (3-chlorophenyl)(3-fluoro-2-(pyridin-2-yloxy)phenyl)methanone 
• 1446517-30-1 (3-fluoro-2-(pyridin-2-yloxy)phenyl)(naphthalen-1-yl)methanone 
• 1446517-31-2 (3-fluoro-2-(pyridin-2-yloxy)phenyl)(naphthalen-2-yl)methanone 
• 1446517-32-3 1-(3-fluoro-2-(pyridin-2-yloxy)phenyl)-3-phenylpropan-1-one 

Relevant academic research and scientific papers

Selective C-H bond fluorination of phenols with a removable directing group: Late-stage fluorination of 2-phenoxyl nicotinate derivatives

A facile and site-selective C-H bond fluorination of phenols using removable 2-pyridyloxy group as an auxiliary was developed. Alternatively, late-stage C-H bond fluorination of bioactive 2-phenoxyl nicotinate derivatives and diflufenican were also feasible under the present strategy.

Nickel-Catalyzed Amination of Aryl 2-Pyridyl Ethers via Cleavage of the Carbon-Oxygen Bond

Reaction of aryl 2-pyridyl ethers with amines was carried out via Ni-catalyzed C-OPy bond cleavage, giving aniline derivatives in reasonable to excellent yields. Both electron-rich and electron-poor aryl 2-pyridyl ethers and a wide range of amines can be used in the transformation. The method provides a conversion way for the 2-pyridyloxy directing group in the C-H bond functionalization reactions.

Synthesis of 2 - fluoro phenol compounds

The present invention provides a method for synthetizing a 2-fluoro phenol compound shown in a formula IV. The phenol compound shown in the formula I is prepared into a 2-pyridine oxygroup arene compound shown in a formula II through an Ullmann reaction, the 2-pyridine oxygroup arene compound shown in the formula II is mixed with a palladium catalyst, a fluorinating reagent, an additive and an organic solvent, the mixture is stirred under the temperature of 30-160 DEG C to perform a fluorination reaction to obtain an ortho-position fluoridated 2-pyridine oxygroup arene compound shown in a formula III, and the ortho-position fluoridated 2-pyridine oxygroup arene compound shown in the formula III is prepared into the 2-fluoro phenol compound shown in the formula IV through the action of alkali. The method provided by the present invention has the advantages of mild reaction conditions, simplicity in operations, good substrate adaptability, high fluorination selectivity and the like. The 2-fluoro phenol compound is shown in the figure below.

Nickel-Catalyzed Borylation of Aryl and Benzyl 2-Pyridyl Ethers: A Method for Converting a Robust ortho-Directing Group

The nickel-catalyzed borylation of aryl 2-pyridyl ethers via the loss of a 2-pyridyloxy group is described. This method allows a 2-pyridyloxy group to be used as a convertible directing group in C?H bond functionalization reactions. The nickel catalyst can also borylate arylmethyl 2-pyridyl ethers, in which the stereochemistry at the benzylic position is retained in the case of chiral secondary benzylic substrates. (Figure presented.).