1357293-82-3

Basic information

• Product Name: N-(3-chlorophenyl)-4-(3-phenoxyphenyl)butanamide
• Synonyms: N-(3-chlorophenyl)-4-(3-phenoxyphenyl)butanamide
• CAS NO: 1357293-82-3
• Molecular Weight: 365.859
• Mol File: 1357293-82-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-chlorophenyl)-4-(3-phenoxyphenyl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chlorophenyl)-4-(3-phenoxyphenyl)butanamide(1357293-82-3)
• EPA Substance Registry System: N-(3-chlorophenyl)-4-(3-phenoxyphenyl)butanamide(1357293-82-3)

Safety Data

• Hazardous Substances Data: 1357293-82-3(Hazardous Substances Data)

Upstream product

• 160721-25-5 ethyl (3-hydroxyphenyl)butanoate 
• 591-50-4 iodobenzene 
• 108-42-9 3-chloro-aniline 
• 1357293-85-6 C₁₈H₂₀O₃ 

Relevant articles and documents

Design, synthesis and evaluation of novel molecules with a diphenyl ether nucleus as potential antitubercular agents

A series of compounds with a diphenyl ether nucleus were synthesized by incorporating various amines into the diphenyl ether scaffold with an amide bond. Their antitubercular activities were evaluated against Mycobacterium tuberculosis H37Rv by a microdilution method, with MIC values ranging from 4 to 64 μg/mL. Through structure-activity relationship studies, the two chlorine atoms at 3 and 4 positions in the phenyl ring of R2 group were found to play a significant role in the antitubercular activity. The most potent compound 6c showed an MIC value of 4 μg/mL and a good safety profile in HepG2 cell line by the MTT assay. Compound 6c was further found to be effective in a murine model of BCG infection, providing a good lead for subsequent optimization.