1357305-59-9

Basic information

• Product Name: {3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}(3-hydroxypiperidin-1-yl)methanone
• Synonyms: {3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}(3-hydroxypiperidin-1-yl)methanone
• CAS NO: 1357305-59-9
• Molecular Weight: 436.338
• Mol File: 1357305-59-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}(3-hydroxypiperidin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: {3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}(3-hydroxypiperidin-1-yl)methanone(1357305-59-9)
• EPA Substance Registry System: {3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}(3-hydroxypiperidin-1-yl)methanone(1357305-59-9)

Safety Data

• Hazardous Substances Data: 1357305-59-9(Hazardous Substances Data)

Upstream product

• 36404-88-3 2-chloro-3-carbaldehydepyridine 
• 791119-12-5 1-benzhydyryl-3-(4-chlorophenyl-2-chloropyrid-3-ylmethoxy)azetidine 
• 80099-85-0 2-chloro-3-(4-chlorobenzoyl)-pyridine 
• 488149-34-4 2-chloro-N-methoxy-N-methyl-pyridine-3-carboxamide 
• 1357306-02-5 C₁₆H₁₃Cl₃N₂O₂ 
• 64051-79-2 piperidin-3-ol hydrochloride 
• 791119-13-6 3-(4-chlorophenyl-2-chloropyrid-3-ylmethoxy)azetidine 
• 49609-84-9 2-Chloronicotinoyl chloride 

Relevant articles and documents

Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity

We describe here our attempts to optimise the human fatty acid amide hydrolase (FAAH) inhibition and physicochemical properties of our previously reported tetrasubstituted azetidine urea FAAH inhibitor, VER-156084. We describe the SAR of a series of analogues and conclude with the demonstration of in vivo dose-dependant FAAH inhibition in an anandamide-loading study in rats.