135733-32-3

Upstream product

• 81400-94-4 4-phenyl-3-furazancarboxylic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 104-54-1 3-Phenylpropenol 
• 135733-30-1 3-(hydroxymethyl)-4-phenylfuroxan 

Downstream Products

• 143423-04-5 4-phenyl-3-furazancarbaldehyde 
• 169614-84-0 2-(2-Oxy-4-phenyl-furazan-3-ylmethyl)-isoindole-1,3-dione 
• 217966-19-3 2-[4-(2-Oxy-4-phenyl-furazan-3-ylmethyl)-piperazin-1-yl]-pyrimidine 
• 217966-10-4 3-chloromethyl-4-phenyl-1,2,5-oxadiazole N²-oxide 
• 135733-34-5 4-phenylfuroxan-3-carboxaldehyde 

Relevant academic research and scientific papers

Synthesis and herbicidal activity of N-oxide derivatives

As part of an ongoing program on the chemistry and biological activity of N-oxide-containing molecules, a number of novel 1,2,5-oxadiazole N-oxide, benzo[1,2-c]1,2,5-oxadiazole N-oxide, and quinoxaline N,N'-dioxide derivatives were synthesized and evaluated for their herbicidal activity. Many of these compounds exhibited moderate to good herbicidal pre-emergence activity against Triticum aestivum. Dose - response studies were done on the more representative compounds (12, 20, and 26). The most active compound, butylcarbamoylbenzo[1,2-c]1,2,5-oxadiazole N-oxide, 26, displayed herbicidal activity at concentrations as low as 24 g/ha.

1,2,5-Oxadiazole N-oxide derivatives as potential anti-cancer agents: Synthesis and biological evaluation. Part IV

Several new 1,2,5-oxadiazole N-oxide derivatives and some deoxygenated analogues were synthesized to be tested as potential selective hypoxic cell cytotoxins. Compounds prepared were designed in order to gain insight into the mechanism of action of this kind of cytotoxin. Compounds were tested in oxia and hypoxia and they proved to be non-selective. 3-Cyano-N2-oxide-4-phenyl-1,2,5-oxadiazole showed the best cytotoxic activity in oxia. The cytotoxicity observed for these derivatives could be explained in terms of the electronic characteristics of the 1,2,5-oxadiazole substituents. Electrochemical and ESR studies were performed on the more cytotoxic derivative.

Unsymmetrically Substituted Furoxans, XIII. Phenylfuroxancarbaldehydes and Related Compounds

The synthesis and structure of two isomeric phenylfuroxancarbaldehydes 7a and 7b, of the phenylfurazancarbaldehyde 6 and of the corresponding alcohols 3a, 3b and 5 are reported.Thermal equilibration of the furoxan derivatives and their oxidation to the co