217966-19-3

Usage

Uses

Used in Pharmaceutical Industry:
Pyrimidine, 2-[4-[(2-oxido-4-phenyl-1,2,5-oxadiazol-3-yl)methyl]-1-piperazinyl]is used as a potential pharmaceutical compound for its possible medicinal properties. The presence of the piperazine moiety, which is commonly found in various medications, and the biological activity of the oxadiazole group suggest that Pyrimidine, 2-[4-[(2-oxido-4-phenyl-1,2,5-oxadiazol-3-yl)methyl]-1-piperazinyl]- may have therapeutic applications. Further research and development are needed to explore its potential uses in the pharmaceutical industry.

Upstream product

• 20980-22-7 N-(2-pyridinyl)piperazine 
• 217966-10-4 3-chloromethyl-4-phenyl-1,2,5-oxadiazole N²-oxide 
• 135733-30-1 3-(hydroxymethyl)-4-phenylfuroxan 
• 135733-32-3 4-phenyl-3-furazanmethanol 
• 104-54-1 3-Phenylpropenol 

Relevant academic research and scientific papers

Synthesis and herbicidal activity of N-oxide derivatives

As part of an ongoing program on the chemistry and biological activity of N-oxide-containing molecules, a number of novel 1,2,5-oxadiazole N-oxide, benzo[1,2-c]1,2,5-oxadiazole N-oxide, and quinoxaline N,N'-dioxide derivatives were synthesized and evaluated for their herbicidal activity. Many of these compounds exhibited moderate to good herbicidal pre-emergence activity against Triticum aestivum. Dose - response studies were done on the more representative compounds (12, 20, and 26). The most active compound, butylcarbamoylbenzo[1,2-c]1,2,5-oxadiazole N-oxide, 26, displayed herbicidal activity at concentrations as low as 24 g/ha.

Synthesis and biological evaluation of 1,2,5-oxadiazole N-oxide derivatives as hypoxia-selective cytotoxins

Synthesis and biological evaluation of new 1,2,5-oxadiazole N-oxide derivatives with potential cytotoxic effects are described. From the series of compounds tested, compounds 2 and 6 proved to be very active, although non-selective.