1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Chemical Name:1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
CAS No.:1357358-05-4
Molecular Formula:C₁₈H₁₈N₄O₂
Molecular Weight:322.367
Hs Code.:

Synonyms:1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Chemical Property of 1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Technology Process of 1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

There total 10 articles about 1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1357192-32-5
5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4-ol

: 7051-34-5
cyclopropylcarbinyl bromide

: 1357358-05-4
1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4-ol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

cyclopropylcarbinyl bromide; In N,N-dimethyl-formamide; at 0 ℃; for 7h;
DOI:10.1016/j.bmc.2016.05.049

Reference yield:

: 1238702-58-3
1-phenyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 1357590-75-0
3-chloro-1-(cyclopropylmethyl)-5-methoxypyridazin-4(1H)-one

: 1357358-05-4
1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate; In water; toluene; for 20h; Reflux; Inert atmosphere;

Reference yield:

: 1126-00-7
1-phenylpyrazole

: 1357358-05-4
1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 21 h / -78 - 20 °C / Inert atmosphere

1.2: pH 5

2.1: toluene / 48 h / 20 - 40 °C

3.1: potassium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / toluene; water / 24 h / Reflux; Inert atmosphere

4.1: hydrogen; 20% palladium hydroxide-activated charcoal / tetrahydrofuran; methanol / 48 h / 20 °C

5.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1.5 h / Cooling with ice; Inert atmosphere

5.2: 16 h / 20 °C

With n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; hexane; N,N-dimethyl acetamide; water; toluene; mineral oil;