1357385-52-4

Basic information

• Product Name: {(2R,3S,11bS)-2-[2-(benzyloxy)ethyl]-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-3-yl}methanol
• CAS NO: 1357385-52-4
• Molecular Weight: 411.541
• Mol File: 1357385-52-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {(2R,3S,11bS)-2-[2-(benzyloxy)ethyl]-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-3-yl}methanol(CAS DataBase Reference)
• NIST Chemistry Reference: {(2R,3S,11bS)-2-[2-(benzyloxy)ethyl]-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-3-yl}methanol(1357385-52-4)
• EPA Substance Registry System: {(2R,3S,11bS)-2-[2-(benzyloxy)ethyl]-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-3-yl}methanol(1357385-52-4)

Safety Data

• Hazardous Substances Data: 1357385-52-4(Hazardous Substances Data)

Upstream product

• 98062-25-0 tert-butyl N-[2-(3,4-dimethoxyphenyl)ethyl]carbamate 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 89923-31-9 (E)-5-(benzyloxy)pent-2-en-1-ol 
• 128217-53-8 5-benzyloxy-2(E)-pentenoic acid methyl ester 
• 100-39-0 benzyl bromide 
• 19790-60-4 3-Benzyloxypropanal 
• 4799-68-2 3-benzyloxypropan-1-ol 

Downstream Products

• 1357385-53-5 (2R,3S,11bS)-2-[2-(benzyloxy)ethyl]-9,10-dimethoxy-3-vinyl-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline 

Relevant articles and documents

Concise total synthesis of dihydrocorynanthenol, protoemetinol, protoemetine, 3-epi-protoemetinol and emetine

A concise asymmetric assembly of secologanine tryptamine and dopamine alkaloids by means of a one-pot three-component cascade reaction methodology is disclosed. This is demonstrated by the expeditious total syntheses of (-)-dihydrocorynanthenol, (-)-protoemetinol, (-)-protoemetine, (-)-3-epi-protoemetinol, and emetine (3-6 steps). The biomimetic synthetic strategy involved the following key steps: (i) One-pot three-component highly enantioselective catalytic Michael/Pictet-Spengler/lactamization cascade reactions; (ii) One-pot tandem Swern oxidation/Wittig sequences; (iii) One-pot tandem hydrogenation sequences. Copyright