13575-86-5 Usage
Description
6-aminotetralin-2,3-diol, also known as 6,7-ADTN HBr, is a broad-spectrum dopamine receptor agonist with a significant selectivity for the human dopamine D3 receptor. It plays a crucial role in modulating synaptic transmission in the nucleus accumbens by activating presynaptic dopamine receptors, making it a potential candidate for various applications in the pharmaceutical and medical fields.
Uses
Used in Pharmaceutical Industry:
6-aminotetralin-2,3-diol is used as a pharmaceutical compound for its agonistic effects on dopamine receptors, particularly the human dopamine D3 receptor. Its selectivity and broad-spectrum activity make it a valuable tool in the development of treatments for various neurological and psychiatric disorders.
Used in Research and Development:
In the field of research and development, 6-aminotetralin-2,3-diol is used as a research tool to study the function and role of dopamine receptors in the central nervous system. Its ability to modulate synaptic transmission in the nucleus accumbens makes it a valuable asset in understanding the underlying mechanisms of various neurological conditions and the development of novel therapeutic strategies.
Used in Drug Interaction Studies:
6-aminotetralin-2,3-diol is also used in studying the interactions between psychostimulants such as cocaine and amphetamine and dopamine receptors. This helps in understanding the effects of these substances on the central nervous system and their potential for addiction and abuse, leading to the development of more effective treatments and interventions for substance use disorders.
References
1) List et al. (1982), Striatal binding of 2-amino-6,7-[3H]dihydroxy-1,2,3,4-tetrahydronaphthalene to two dopaminergic sites distinguished by their low and high affinity for neuroleptics; J. Neurosci., 2 895
2) Templeton et al. (1982), Binding of [3H]ADTN to rat striatal membranes; Biochem. Pharmacol., 31 1629
3) Freedman et al. (1994), Expression and pharmacological characterization of the human D3 dopamine receptor; Curr. J. Pharmacol. Exp. Ther., 268 417
4) Nicola et al. (1996), Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors; J. Neurosci., 16 1591
Check Digit Verification of cas no
The CAS Registry Mumber 13575-86-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,5,7 and 5 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 13575-86:
(7*1)+(6*3)+(5*5)+(4*7)+(3*5)+(2*8)+(1*6)=115
115 % 10 = 5
So 13575-86-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO2.BrH/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8;/h4-5,8,12-13H,1-3,11H2;1H
13575-86-5Relevant articles and documents
A Concise Synthesis of 2-Amino-1,2,3,4-tetrahydronaphthalene-6,7-diol ('6,7-ADTN') from Naphthalene-2,3-diol
Goeksu, Sueleyman,Kazaz, Cavit,Suetbeyaz, Yasar,Secen, Hasan
, p. 3310 - 3313 (2007/10/03)
2-Amino-1,2,3,4-tetrahydronaphthalene-6,7-diol (2; 6,7-ADTN) was synthesized starting from naphthalene-2,3-diol in seven steps and with an overall yield of 44%. Methylation of naphthalene-2,3-diol with dimethyl sulfate, followed by Friedel-Crafts acylatio
Modified synthesis of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene
Schrotter,Bunte,Schick,Niedrich
, p. 88 - 91 (2007/10/02)
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