82205-66-1Relevant academic research and scientific papers
Brain Levels and Metabolism of the Dopaminergic Agonist 2-Amino-6,7-dihydroxytetrahydronaphthalene After Administration of Various Prodrugs
Horn, A. S.,Griever-Kazemier, H.,Dijkstra, D.
, p. 993 - 996 (1982)
The synthesis of four prodrug diesters (diacetyl, diisobutyryl, dipivaloyl, and dibenzoyl) of the potent dopaminergic agonist 2-amino-6,7-dihydroxytetrahydronaphthalene (6,7-ADTN) is described.The effects of prodrug structure on the levels of 6,7-ADTN in the rat corpus striatum and cerebellum, as well as the levels of the metabolite, 6-hydroxy-7-methoxy-2-aminotetralin, in the corpus striatum, have been determined after intraperitoneal administration.In addition, the stratial levels of 6,7-ADTN after administration of the dibenzoyl analogue via intraperitoneal, subcutaneous, and oral routes have been measured.These prodrugs produce a significant improvement in the penetration and accumulation of 6,7-ADTN in the brain.
