1357592-87-0

Upstream product

• 111335-53-6 3-chloro-5-methoxy-4(1H)-pyridazinone 
• 4333-56-6 cyclopropyl bromide 
• 1357192-32-5 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4-ol 
• 1357192-31-4 1-benzyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 
• 1357192-30-3 1-benzyl-3-chloro-5-methoxypyridazin-4(1H)-one 
• 2096-22-2 3-chloro-4,5-dimethoxypyridazine 
• 1238702-58-3 1-phenyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 
• 1238702-56-1 (1-phenyl-1H-pyrazol-5-yl)boronic acid 
• 1126-00-7 1-phenylpyrazole 

Relevant academic research and scientific papers

Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket

Utilizing structure-based drug design techniques, we designed and synthesized phosphodiesterase 10A (PDE10A) inhibitors based on pyridazin-4(1H)-one. These compounds can interact with Tyr683 in the PDE10A selectivity pocket. Pyridazin-4(1H)-one derivative

HETEROCYCLIC COMPOUND AND USE THEREOF

The present invention aims to provide a compound having a PDE inhibitory action and useful as a medicament for the prophylaxis or treatment of schizophrenia and the like. A compound represented by the formula (1x): wherein each symbol is as des