13578-99-9

Usage

Derivative of indenone

The compound is derived from indenone, which is a class of chemical compounds that are tricyclic in structure.

Found in mulberry roots

The compound is naturally occurring in the roots of Morus alba L., commonly known as the mulberry tree.

Traditional Chinese medicine

Dihydromorin has been used in traditional Chinese medicine for its various therapeutic properties.

Anti-inflammatory properties

The compound has the ability to reduce inflammation, which can be useful in treating various inflammatory conditions.

Antioxidant properties

Dihydromorin can neutralize free radicals, helping to prevent oxidative stress and damage to cells.

Antibacterial properties

The compound has the ability to inhibit the growth of bacteria, making it a potential candidate for treating bacterial infections.

Potential therapeutic effects on various diseases

Dihydromorin has been studied for its potential effects on diseases such as cancer, diabetes, and cardiovascular diseases.

Promising candidate for pharmaceutical drug development

Due to its chemical structure and properties, dihydromorin is considered a promising candidate for further research and potential development of new pharmaceutical drugs.

Upstream product

• 83-33-0 inden-1-one 
• 591-31-1 3-methoxy-benzaldehyde 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 61463-59-0 2-allyl benzoic acid methyl ester 
• 10365-98-7 3-methoxyphenylboronic acid 
• 609-67-6 2-Iodobenzoyl chloride 
• 73178-23-1 N-benzyl-2-iodobenzamide 
• 88-67-5 2-Iodobenzoic acid 
• 325142-84-5 3-methoxyphenylboronic acid pinacol ester 

Downstream Products

• 13579-03-8 2.2-Bis-(m-methoxy-benzyl)-1-indanon 
• 1376128-36-7 (R)-N-(2-fluoro-2-(3-methoxybenzyl)-2,3-dihydro-1H-inden-1-ylidene)benzamide 

Relevant academic research and scientific papers

Iridium-catalyzed chemoselective transfer hydrogenation of α, β-unsaturated ketones to saturated ketones in water

A chemoselective iridium-catalyzed transfer hydrogenation of α, β-unsaturated ketones was realized in water. The C[dbnd]C double bonds of 2-benzylidene indanones and analogues were hydrogenated exclusively catalyzed by an iridium complex (0.1 mol%) bearin

Nickel-Catalyzed Domino Heck-Type Reactions Using Methyl Esters as Cross-Coupling Electrophiles

While esters are frequently used as traditional electrophiles in substitution chemistry, their application in cross-coupling chemistry is still in its infancy. This work demonstrates that methyl esters can be used as coupling electrophiles in Ni-catalyzed Heck-type reactions through the challenging cleavage of the C(acyl)?O bond under relatively mild reaction conditions at either 80 or 100 °C. With the σ-NiII intermediate generated from the insertion of acyl NiII species into the tethered C=C bond, carbonyl-retentive products were formed by domino Heck/Suzuki–Miyaura coupling and Heck/reduction pathways when organoboron and mild hydride nucleophiles are used.

Ni-Catalyzed Alkene Carboacylation via Amide C-N Bond Activation

We report Ni-catalyzed formal carboacylation of o-allylbenzamides with arylboronic acid pinacol esters. The reaction is triggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceeds via alkene insertion into a Ni(II)-acyl bond. The exo-selective carboacylation reaction generates 2-benzyl-2,3-dihydro-1H-inden-1-ones in moderate to high yields (46-99%) from a variety of arylboronic acid pinacol esters and substituted o-allylbenzamides. These results show that amides are practical substrates for alkene carboacylation via amide C-N bond activation, and this approach bypasses challenges associated with alkene carboacylation triggered by C-C bond activation.