1357923-35-3Relevant academic research and scientific papers
NOVEL COMPOUNDS
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Page/Page column 326, (2019/11/19)
The present invention relates to substituted 5-membered nitrogen containing heteroaryl compounds, such as sulfonyl triazoles, where the heteroaryl ring is further substituted, optionally via a linking group such as -NH-, with a cyclic group which in turn is substituted at the α-position. The present invention further relates to associated salts, solvates, prodrugs and pharmaceutical compositions, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.
4 -Aminopyridine derivative, pharmaceutical composition, preparation method and application thereof
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Paragraph 0194; 0195, (2019/04/30)
The invention discloses a 4-aminopyridine derivative, a preparation method, a pharmaceutical composition and application thereof. The 4-aminopyridine derivative (I), an isomer, a prodrug, a stable isotope derivative or a pharmaceutically acceptable salt thereof have the following structure shown in the specification. The 4-aminopyridine derivative has a good adenosine A2a receptor antagonist effect, and related diseases such as cancer, central nervous system diseases and the like caused by adenosine A2a receptor level disorder can be effectively treated or relieved.
BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE
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Page/Page column 256-257, (2012/02/15)
Compounds of Formula (I) are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula (I) have the following structure: where the definitions of the variables are provided herein.
