135793-89-4

Upstream product

• 108-91-8 cyclohexylamine 
• 1895-97-2 2-methyl-3-phenylacrylic acid 
• 135793-88-3 (Z)-2-Acetylsulfanylmethyl-3-phenyl-acrylic acid 

Relevant academic research and scientific papers

Amino acid, derivatives, processes for their preparation and their therapeutic application

New amino acid derivatives, processes for their preparation and their therapeutic application. Amino acid derivatives corresponding to the general formulae STR1 These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity.

Studies on the structural feature of S1 subsite of neprilysin (EC.3.4.24.11): Stereochemical requirement for the enzyme-inhibitor docking process

The preferred conformation of thiorphan during the inhibitor-neprilysin docking process was investigated. A series of achiral inhibitors were tested. This study led to the design of a potent inhibitor, in which the ethylenic bond bears the aryl residue of P'1.