135793-88-3Relevant academic research and scientific papers
The synthesis of (S)-3-acetylthio-2-benzylpropionic acid from (Z)-2-chloromethyl-3-phenylprop-2-enoic acid by asymmetric hydrogenation: A chiral building block of an enkephalinase inhibitor
Yuasa, Yoko,Yuasa, Yoshifumi,Tsuruta, Haruki
, p. 511 - 514 (2007/10/03)
(S)-2-Benzyl-3-chloropropionic acid (7) was synthesized from (Z)-2-(chloromethyl)-3-phenylprop-2-enoic acid (5) by asymmetric hydrogenation with a ruthenium 2,2′-bis(di-p-tolylphosphino)-1,1′-binaphthyl complex in the presence of triethylamine. Acetylthio
Studies on the structural feature of S1 subsite of neprilysin (EC.3.4.24.11): Stereochemical requirement for the enzyme-inhibitor docking process
Danvy, Denis,Monteil, Thierry,Plaquevent, Jean-Christophe,Duhamel, Lucette,Duhamel, Pierre,Gros, Claude,Noel, Nadine,Schwartz, Jean-Charles,Lecomte, Jeanne-Marie
, p. 2437 - 2440 (2007/10/03)
The preferred conformation of thiorphan during the inhibitor-neprilysin docking process was investigated. A series of achiral inhibitors were tested. This study led to the design of a potent inhibitor, in which the ethylenic bond bears the aryl residue of P'1.
