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21901-34-8

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21901-34-8 Usage

Chemical Properties

Green-yellow solid

Check Digit Verification of cas no

The CAS Registry Mumber 21901-34-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,9,0 and 1 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 21901-34:
(7*2)+(6*1)+(5*9)+(4*0)+(3*1)+(2*3)+(1*4)=78
78 % 10 = 8
So 21901-34-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H6N2O3/c1-4-2-5(8(10)11)3-7-6(4)9/h2-3H,1H3,(H,7,9)

21901-34-8 Well-known Company Product Price

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  • Alfa Aesar

  • (L19866)  2-Hydroxy-3-methyl-5-nitropyridine, 97%   

  • 21901-34-8

  • 1g

  • 324.0CNY

  • Detail
  • Alfa Aesar

  • (L19866)  2-Hydroxy-3-methyl-5-nitropyridine, 97%   

  • 21901-34-8

  • 5g

  • 1178.0CNY

  • Detail
  • Aldrich

  • (736953)  2-Hydroxy-3-methyl-5-nitropyridine  97%

  • 21901-34-8

  • 736953-1G

  • 187.20CNY

  • Detail
  • Aldrich

  • (736953)  2-Hydroxy-3-methyl-5-nitropyridine  97%

  • 21901-34-8

  • 736953-5G

  • 625.95CNY

  • Detail

21901-34-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-methyl-5-nitro-1H-pyridin-2-one

1.2 Other means of identification

Product number -
Other names 5-Nitro-2-hydroxy-3-methyl-pyridin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:21901-34-8 SDS

21901-34-8Relevant articles and documents

RING TRANSFORMATIONS OF 5-NITROPYRIMIDINE VIA INVERSE DIELS-ALDER REACTIONS

Charushin, Valery N.,van der Plas, Henk C.

, p. 3965 - 3968 (1982)

5-Nitropyrimidine undergoes inverse Diels-Alder cycloadditions with ketene-N,N-, -O,O- acetals and enamines resulting in pyridine derivatives.The 1H NMR evidence for the 1-N,N-diethylaminopropyne cycloadduct formation is presented.

Computer-aided discovery of aminopyridines as novel JAK2 inhibitors

Zhao, Chao,Yang, Su Hui,Khadka, Daulat Bikram,Jin, Yifeng,Lee, Kyung-Tae,Cho, Won-Jea

, p. 985 - 995 (2015)

The Janus kinase 2 (JAK2)-mediated signaling pathway plays an important role in controlling cell survival, proliferation, and differentiation. In recent years, genetic, biological, and physiological evidence has established JAK2 inhibitors as effective chemotherapeutic agents for the treatment of many different cancers. For this reason, we sought to identify novel small molecule inhibitors of JAK2. Using Surflex-Dock software, we tested 3010 compounds with known chemical structures in silico for their ability to interact with the JAK2 ATP-binding pocket. We selected the 10 highest-scoring compounds and tested their abilities to inhibit JAK2 activity in vitro. Compound 1a (ethyl 1-(5-((3-methoxyphenyl)carbamoyl)-3-nitropyridin-2-yl)piperidine-4-carboxylate) was identified. Optimization of 1a using docking studies led to the discovery of compounds 1b and 1d, potent JAK2 inhibitors. Furthermore, as V-shaped kinase inhibitors can curve around the protein backbone and access deep into the pocket, we developed a new series of compounds with a non-linear sulfonamide bond. Nine compounds were prepared and evaluated for JAK2 inhibitory effects. Compounds 7e (IC50 = 6.9 μM) and 7h (IC50 = 12.2 μM) showed better JAK2 inhibition, validating our design approach. This study successfully applied virtual screening for hit discovery, and a docking study for hit optimization. In addition, a novel approach to drug discovery, combining structure- and shape-based drug design, facilitated the design of more potent JAK2 inhibitors. The methods provide a guide for future development of inhibitors targeting JAK2 and other kinases.

IMIDAZOPYRROLIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE

-

Page/Page column 67, (2014/12/12)

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Pyrazinone Modulator of Corticotropin-Releasing Factor Receptor Activity

-

Page/Page column 5; 13-14, (2010/03/02)

The invention relates to the compound (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile, pharmaceutical compositions of the compound, and methods of using the compound for the treatment of psychiatric disorders and neurological diseases including depression, anxiety related disorders, irritable bowel syndrome, addiction and negative aspects of drug and alcohol withdrawal, and other conditions associated with CRF.

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