135822-92-3

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 630-19-3 pivalaldehyde 
• 127-65-1 chloroamine-T 
• 6873-55-8 p-tolylsulfinyl amide 
• 174464-96-1 C₁₂H₁₇NOS 
• 88303-17-7 N-fluoro-N-2,2-dimethylpropyl-p-toluenesulfonamide 
• 959865-52-2 4-Methyl-benzenesulfinic acid [2,2-dimethyl-prop-(E)-ylidene]-amide 
• 103-19-5 di(p-tolyl) disulfide 
• 672-78-6 methyl p-toluene sulfinate 

Downstream Products

• 1006605-83-9 (C₅H₅)Fe(CH₃C₆H₄SOC₅H₃CH(C(CH₃)3)NHSO₂C₆H₄CH₃) 
• 1197132-25-4 (S)-N-(1-(dinaphthalen-1-ylphosphoryl)-2,2-dimethylpropyl)-4-methylbenzenesulfonamide 
• 1266329-75-2 C₃₉H₇₃NO₇SSi₃ 
• 1384170-43-7 N-(1-cyano-1,1-difluoro-3,3-dimethylbutan-2-yl)-4-methylbenzenesulfonamide 
• 1432610-52-0 (2E)-ethyl 2-(N-(tert-butyl)-N'-tosylcarbamimidoyl)-4,4-dimethylpent-2-enoate 
• 88303-23-5 N-(2,2-dimethylpropyl)-4-methylbenzenesulphonamide 

Relevant academic research and scientific papers

Two-Step Asymmetric Synthesis of Disubstituted N-Tosyl Aziridines Having 98-100% ee: Use of a Phosphazene Base

Unknown diaryl (1-3) and alkyl-phenyl (4, 5) N-tosyl aziridines have been successfully synthesized from pure (R,R,R,SS)-(-)-sulfonium salt derived from Eliel's oxathiane, tosylimines 11a-f, and using a phosphazene base (EtP2) to gene

Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures

We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.

NHC ligand-enabled Ni-catalyzed reductive coupling of alkynes and imines using isopropanol as a reductant

A nickel-catalyzed reductive coupling of alkynes and imines using readily available isopropanol as the reducing agent was developed. The use of a sterically bulky and electron-rich carbene ligand (AnIPr) significantly promotes the reaction, providing various multi-substituted allylic amines in 23-89% yield and the corresponding chiral ligand (AnIPr-3) can afford the products in 51-95% ee.

Alkenyl Exchange of Allylamines via Nickel(0)-Catalyzed C-C Bond Cleavage

A functional group exchange reaction between allylamines and alkenes via nickel-catalyzed C - C bond cleavage and formation was developed. This reaction provides a novel protocol, which does not require the use of unstable imine substrates, for the synthesis of allylamines, which are widely used in the production of fine chemicals, pharmaceuticals, and agrochemicals.

Verkade's Superbase as an Organocatalyst for the Strecker Reaction

Proazaphosphatranes -Verkade's superbases- proved to be efficient organocatalysts for the Strecker reaction between protected imines and trimethylsilyl cyanide (TMSCN). Excellent to quantitative yields were reached and, compared to other systems, only low

Palladium-Catalyzed Direct Intramolecular C-N Bond Formation: Access to Multisubstituted Dihydropyrroles

A palladium-catalyzed intramolecular amination of alkenes with retention of olefin functionalization was achieved under mild reaction conditions. In the presence of palladium catalyst, the tosyl-protected amine can directly couple with a double bond to provide versatile dihydropyrrole derivatives in moderate to excellent yields.

Asymmetric Arylation of Imines Catalyzed by Heterogeneous Chiral Rhodium Nanoparticles

Asymmetric arylation of aldimines catalyzed by heterogeneous chiral rhodium nanoparticles has been developed. The reaction proceeded in aqueous media without significant decomposition of the imines by hydrolysis to afford chiral (diarylmethyl)amines in high yields with outstanding enantioselectivities. This catalyst system exhibited the highest turnover number (700) in heterogeneous catalysts reported to date for these reactions. The reusability of the catalyst was also demonstrated.

Aza-Morita-Baylis-Hillman reactions catalyzed by a cyclopropenylidene

Catalysis using a bis(dialkylamino)cyclopropenylidene (BAC) has been developed, which relies on a formal umpolung activation of Michael acceptor pro-nucleophiles. Various aza-Morita-Baylis-Hillman reactions between aromatic, heteroaromatic, or aliphatic imines and acyclic or cyclic α,β-unsaturated ketones and carboxylic acid derivatives have been catalyzed by a BAC under mild conditions. Functionalities such as unprotected amino and hydroxy groups have been tolerated. The catalyst loading was decreased to 1 mol% without loss of activity. The BAC catalyst was shown to be substantially more active than a cyclic (alkyl)(amino) carbene (CAAC), N-heterocyclic carbenes (NHCs), and P- or N-centered Lewis bases.

Chemoselective Boron-Catalyzed Nucleophilic Activation of Carboxylic Acids for Mannich-Type Reactions

The carboxyl group (COOH) is an omnipresent functional group in organic molecules, and its direct catalytic activation represents an attractive synthetic method. Herein, we describe the first example of a direct catalytic nucleophilic activation of carbox

A General Method for Imine Formation Using B(OCH2CF3)3

Tris(2,2,2-trifluoroethyl)borate [B(OCH2CF3)3] was found to be a mild and general reagent for the formation of a variety of imines by condensation of amides or amines with carbonyl compounds. N-Sulfinyl, N-toluenesulfonyl,