135838-04-9

Basic information

• Product Name: 6-fluoroquinolin-8-ol
• CAS NO: 135838-04-9
• Molecular Weight: 163.151
• Mol File: 135838-04-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 6-fluoroquinolin-8-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoroquinolin-8-ol(135838-04-9)
• EPA Substance Registry System: 6-fluoroquinolin-8-ol(135838-04-9)

Safety Data

• Hazardous Substances Data: 135838-04-9(Hazardous Substances Data)

Usage

General Description

6-fluoroquinolin-8-ol, also known as 6-fluoro-(8-hydroxyquinoline), is a type of chemical compound with the molecular formula C9H6FNO. 6-fluoroquinolin-8-ol belongs to the class of organic compounds known as fluoroquinolines, which are heterocyclic compounds containing a quinoline moiety substituted by one or more fluorine atoms. It is characterized by the presence of a quinoline system bearing a fluoro substituent at the 6-position and a hydroxy group at the 8-position. Detailed information about its physical properties and usages is limited, and further research is essential to determine its potential use in industrial or medicinal applications.

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Relevant articles and documents

Fluorinated Alq3 derivatives with tunable optical properties

This communication reports that not only the emission colour but also the photoluminescence quantum yield of Alq3 can be tuned by introducing fluorine atoms at different positions; with fluorination at C-5 the emission is red-shifted with a tremendously decreased intensity, fluorination at C-6 causes a blue-shift with a significantly increased intensity, and fluorination at C-7 has a minor effect on both the colour and intensity of Alq3's emission. The Royal Society of Chemistry 2006.

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

There is interest in developing potent, selective, and cell-permeable inhibitors of human ferrous iron and 2-oxoglutarate (2OG) oxygenases for use in functional and target validation studies. The 3-component Betti reaction enables efficient one-step C-7 functionalisation of modified 8-hydroxyquinolines (8HQs) to produce cell-active inhibitors of KDM4 histone demethylases and other 2OG oxygenases; the work exemplifies how a template-based metallo-enzyme inhibitor approach can be used to give biologically active compounds.

QU1NOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA

The present invention relates to compounds of formula (I) and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various diseases, such as allergic rhinitis.