1358465-22-1

Basic information

• Product Name: (2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine
• Synonyms: (2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine
• CAS NO: 1358465-22-1
• Molecular Weight: 377.406
• Mol File: 1358465-22-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine(1358465-22-1)
• EPA Substance Registry System: (2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine(1358465-22-1)

Safety Data

• Hazardous Substances Data: 1358465-22-1(Hazardous Substances Data)

Upstream product

• 56613-80-0 D-2-phenylglycinol 
• 1358465-41-4 (2R,4R)-2-trifluoromethyl-2-methyl-4-phenyl-3-propanoyloxazolidine 
• 100-39-0 benzyl bromide 
• 1358465-38-9 (2S,4R)-2-trifluoromethyl-2-methyl-4-phenyl-3-propanoyloxazolidine 
• 1358465-35-6 (2R,4R)-2-methyl-2-trifluoromethyl-4-phenyloxazolidine 
• 1202059-62-8 (2S,4R)-2-methyl-4-phenyl-2-trifluoromethyl-1,3-oxazolidine 

Downstream Products

• 1358465-28-7 (S)-2-methyl-N-(1-phenylvinyl)-3-phenylpropanamide 
• 7384-80-7 (S)-2-methyl-3-phenylpropan-1-ol 
• 1358465-34-5 (R)-2-(2,2,2-trifluoro-1-methylethylamino)-2-phenylethanol 

Relevant articles and documents

2-Trifluoromethyl-2-methyl-4-phenyloxazolidine: A new chiral auxiliary for highly diastereoselective enolate alkylation

The alkylation reactions of an amide sodium enolate derived from a C-2 disubstituted trifluoromethylated oxazolidine (Fox) chiral auxiliary occurred in good yields with a very high diastereoselectivity (>98% de). Compared to the C-2 monosubstituted trifluoromethyl analogue, this chiral auxiliary is much more stable towards bases at temperature over -35 °C because the dehydrofluorination reaction is avoided. However asymmetric enolates quaternarization was not successfully achieved with this new chiral auxiliary.