1358604-10-0Relevant academic research and scientific papers
N-Heterocyclic carbene catalyzed esterification of aromatic aldehydes with alcohols under aerobic conditions
Kiran, I. N. Chaithanya,Lalwani, Komal,Sudalai, Arumugam
, p. 1695 - 1698 (2013)
A simple, organocatalytic procedure for the direct oxidative esterification of a variety of aromatic aldehydes with alcohols has been described that affords the corresponding aromatic esters in high yields. The method employs N-heterocyclic carbenes as catalysts and molecular O2 as an oxidant under ambient conditions.
N-heterocyclic carbene-catalyzed oxidative esterification reaction of aldehydes with alkyl halides under aerobic conditions
Xin, Yang-Chun,Shi, Shi-Hui,Xie, Dong-Dong,Hui, Xin-Ping,Xu, Peng-Fei
scheme or table, p. 6527 - 6531 (2011/12/22)
An efficient N-heterocyclic carbene-catalyzed oxidative esterification reaction of aldehydes with alkyl halides or alkyl 4-methylbenzenesulfonate is reported. It was worth noting that (1) the configuration of alkyl halides or alkyl 4-methylbenzenesulfonates was inverted completely, and (2) the presence of oxygen was crucial for this transformation. The reaction proceeded smoothly under mild conditions and various esters were afforded in moderate to good yields. In addition, we have developed an efficient tandem oxidation/ esterification reaction of alcohols. This methodology provides a rare example of a reaction of the Breslow intermediate to sp3-carbon centered electrophiles. An efficient oxidative esterification reaction of aldehydes with alkyl halides or alkyl 4-methylbenzenesulfonates catalyzed by N-heterocyclic carbenes is reported. Oxygenwas crucial for the reaction, and the configuration of alkyl 4-methylbenzenesulfonate was completely inverted. Copyright
