1358788-65-4Relevant academic research and scientific papers
Novel supramolecular organocatalysts of hydroxyprolinamide based on calix[4]arene scaffold for the enantioselective Biginelli reaction
Li, Zhengyi,Xing, Huaijie,Huang, Guoli,Sun, Xiaoqiang,Jiang, Juli,Wang, Leyong
, p. 1726 - 1734 (2012/04/18)
A series of novel supramolecular organocatalysts of hydroxyprolinamide based on the upper rim of calix[4]arene scaffold have been developed to catalyze enantioselective multi-component Biginelli reaction. Under the optimal conditions, the reactions occurred with moderate-to-excellent enantioselectivities (up to 98% ee). A plausible transition state constructed by the supramolecular interaction of hydrogen bond and cation-π between catalysts and substrates has been proposed.
