7244-78-2

Usage

Uses

Used in Organic Synthesis:
4-N-Butoxynitrobenzene is used as a key intermediate in organic synthesis for its ability to undergo various chemical reactions, facilitating the creation of a wide array of organic compounds.
Used in Dye Production:
In the dye industry, 4-N-Butoxynitrobenzene is utilized as a precursor for the synthesis of dyes, contributing to the development of colorants for textiles, plastics, and other materials.
Used in Pesticide Manufacturing:
4-N-Butoxynitrobenzene plays a crucial role in the production of pesticides, serving as a building block for the synthesis of active ingredients that help protect crops and control pests.
Used in Pharmaceutical Industry:
4-N-BUTOXYNITROBENZENE is also used as a precursor in the pharmaceutical industry for the synthesis of various drugs, highlighting its importance in the development of new medicinal compounds.
Used as an Intermediate in Other Organic Compounds Manufacturing:
Due to its chemical versatility, 4-N-Butoxynitrobenzene is employed as an intermediate in the manufacturing of other organic compounds, further expanding its applications across different industries.

InChI:InChI=1/C10H13NO3/c1-2-3-8-14-10-6-4-9(5-7-10)11(12)13/h4-7H,2-3,8H2,1H3

Upstream product

• 109-65-9 1-bromo-butane 
• 100-02-7 4-nitro-phenol 
• 1124-31-8 potassium 4-nitrophenolate 
• 109-69-3 n-Butyl chloride 
• 824-78-2 4-nitrophenol sodium salt 
• 1643-19-2 tetrabutylammomium bromide 
• 100-00-5 4-chlorobenzonitrile 
• 71-36-3 butan-1-ol 
• 636-98-6 p-nitrobenzene iodide 
• 586-78-7 para-nitrophenyl bromide 
• 54519-10-7 (allyl)(n-C₄H₉)3NBr 
• 350-46-9 4-Fluoronitrobenzene 
• 542-69-8 1-iodo-butane 

Downstream Products

• 31309-83-8 2-Butoxy-α-chlor-5-nitrotoluol 
• 17051-01-3 4,4'-di-n-butyloxyazoxybenzene 
• 31309-84-9 2-Butoxy-5-nitro-α-heptyloxy-toluol 
• 31309-85-0 2-Butoxy-5-nitro-α-octyloxy-toluol 
• 31309-86-1 2-Butoxy-5-nitro-α-nonyloxy-toluol 
• 49797-24-2 1-Butoxy-2-iodomethyl-4-nitro-benzene 
• 49798-73-4 1-Butoxy-4-nitro-2-propoxymethyl-benzene 
• 49798-74-5 4-Butoxy-3-propoxymethyl-phenylamine 
• 183323-89-9 ClHgC₆H₃(NO₂)OC₄H₉ 
• 100-02-7 4-nitro-phenol 
• 1377324-61-2 C₃₂H₃₈N₄O₅ 
• 1358788-65-4 C₁₅H₂₂N₂O₃ 
• 1358788-66-5 C₂₀H₃₀N₂O₅ 
• 183323-92-4 N(CH₃)4⁽¹⁺⁾*AuCl₃(O₂NC₆H₃OC₄H₉)^(1-) = [N(CH₃)4][AuCl₃(O₂NC₆H₃OC₄H₉)] 

Relevant academic research and scientific papers

Ultrasound assisted the preparation of 1-butoxy-4-nitrobenzene under a new multi-site phase-transfer catalyst - Kinetic study

In the present research work deals with the preparation of 1-butoxy-4-nitrobenzene was successfully carried out by 4-nitrophenol with n-butyl bromide using aqueous potassium carbonate and catalyzed by a new multi-site phase-transfer catalyst (MPTC) viz.,

Aryl Ether Syntheses via Aromatic Substitution Proceeding under Mild Conditions

In this study, mild conditions for aromatic substitutions during the syntheses of aryl ethers were developed. In the reaction conditions, the choices of solvent, base, and the sequence for the addition of the reagents proved important. A wide variety of alcohols were used directly as nucleophiles and smoothly reacted with aryl chlorides that possessed either a nitro or a cyano group at either the ortho- or para-position. Controlled experiments we performed suggested that the reaction underwent a charge-transfer process mediated by a combination of DMF and tert-BuOK.

Synthesis and antimicrobial studies of new antibacterial azo-compounds active against staphylococcus aureus and listeria monocytogenes

Some novel (phenyl-diazenyl)phenols (4a–m) were designed and synthesized to be evaluated for their antibacterial activity. Starting from an active previously-synthesized azobenzene chosen as lead compound, we introduced some modifications and optimization of the structure, in order to improve solubility and drug conveyance. Structures of all newly-synthesized compounds were confirmed by 1H nuclear magnetic resonance (NMR), mass spectrometry, and UV-Vis spectroscopy. Antibacterial activity of the new compounds was tested with the dilution method against the bacteria strains Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa PAO1. All the compounds were selectively active against Gram-positive bacteria. In particular, compounds 4d, 4h, and 4i showed the highest activity against S. aureus and Listeria monocytogenes, reaching remarkable MIC100 values of 4 μg/mL and 8 μg/mL. The relationship between antimicrobial activity and compound structure has suggested that the presence of hydroxyl groups seems to be essential for antimicrobial activity of phenolic compounds.

Alkoxylation of 4-chloronitrobenzene with aliphatic alcohols and glycols in the presence of NaOH

The reaction of 4-chloronitrobenzene with aliphatic C1-n-C 4 alcohols and with mono-, di-, and triethylene glycols in the presence of NaOH in liquid ammonia at 15-50°C was studied.

Liquid-crystalline polymorphism of 4-heptyloxybenzylidene-4′- alkyloxyanilines and their phase equilibrium with 4-octyloxyphenyl 4-nitrobenzoate

This paper describes the synthesis and liquid-crystalline properties of the homologous series of 4-heptyloxybenzylidene-4′-alkyloxyanilines (7-n). Six of them are presented for the first time. Based on the polarization microscopy (POM and TOA methods) and the calorimetric (DSC) measurements following polymorphism has been detected: nematic, smectic C and smectic I mesophases. The presence of these mesophases was confirmed by the miscibility method, using 4-octyloxyphenyl 4-nitrobenzoate and terephtal-bis (4-butyloaniline) as a mesophase references. Extraordinary results have been found in the mixtures of the investigated compounds with 4-octyloxyphenyl 4-nitrobenzoate; Induced smectic A has been observed, which is connected with very strong intermolecular interactions. Additionally destabilization of nematic and smectic C phases was visible.

Bis(μ-iodo)bis[(-)-sparteine]-dicopper: A versatile catalyst for direct O-Arylation and O-Alkylation of phenols and aliphatic alcohols with haloarenes

The easy to prepare dimeric bis(μ-iodo)bis[(-)-sparteine]- dicopper ([CuI{(-)-spa}]2 complex) is shown to be versatile catalyst for O-arylation and O-alkylation with various aryl halides with phenols and aliphatic alcohols respectively, including less reactive aryl chlorides, such as chlorobenzene under mild conditions.

Novel supramolecular organocatalysts of hydroxyprolinamide based on calix[4]arene scaffold for the enantioselective Biginelli reaction

A series of novel supramolecular organocatalysts of hydroxyprolinamide based on the upper rim of calix[4]arene scaffold have been developed to catalyze enantioselective multi-component Biginelli reaction. Under the optimal conditions, the reactions occurred with moderate-to-excellent enantioselectivities (up to 98% ee). A plausible transition state constructed by the supramolecular interaction of hydrogen bond and cation-π between catalysts and substrates has been proposed.

Novel Prolinamide Organocatalysts Based on Calix[4]arene Scaffold for the Enantioselective Direct Aldol Reaction

A series of novel prolinamide organocatalysts based on calix[4]arene scaffold have been developed to catalyze the direct asymmetric aldol reaction of aromatic aldehydes and cyclohexanone. Under the optimal condition, high isolated yields (up to 99%) and enantioselectivities (up to 97% ee), and moderate diastereoselectivities (up to 85/15) were obtained.

Synthesis of alkyl-aryl ethers by copper-catalyzed etherization reactions of aryl fluorides with tetraalkylammonium bromides and H2O

Synthesis of alkyl aryl ethers via copper-catalyzed etherizations of electron-deficient aryl fluorides with quaternary ammonium bromides and water has been developed. In the presence of Cu(OAc)2, POPh3 (L4) and Cs2CO3, a variety of electron-deficient aryl fluorides underwent the reaction with quaternary ammonium bromides and H 2O in moderate to good yields. The mechanism was also discussed. Synthesis of alkyl aryl ethers via copper-catalyzed etherizations of electron-deficient aryl fluorides with quaternary ammonium bromides and water has been developed. In the presence of Cu(OAc)2, POPh3 (L4) and Cs2CO3, a variety of electron-deficient aryl fluorides underwent the reaction with quaternary ammonium bromides and H 2O in moderate to good yields. Copyright

Fused ring compound and use thereof

The present invention provides a compound represented by the formula: wherein the symbols are as described in the specification, or a salt thereof, which is useful for preventing/treating eicosanoid-associated diseases such as atherosclerosis, diabetes, obesity, atherothrombosis, asthma, fever, pain, cancer, rheumatism, osteoarthritis and atopic dermatitis, and which has an excellent pharmacological action, physicochemical properties, etc.