135885-85-7Relevant academic research and scientific papers
Michael additions of active methylene compounds to chalcones promoted by samarium(III) iodide
Ma, Yongmin,Zhang, Yongmin
, p. 819 - 823 (2002)
Promoted by SmI3, α,β-unsaturated ketones reacted with malononitrile, ethylcyanoacetate, diethylmalonate, β-ketoester or nitromethane to give the 1,4-adducts in moderate to good yields.
A mild, chemoselective, one-pot synthesis of δ-keto α-cyano esters by organocatalysis
Liu, Gang,Wang, Yingcai
, p. 189 - 192 (2014/01/06)
A sequential condensation of α-cyano esters, aldehydes, and ketones with catalytic amount of pyrrolidine/HOAc at room temperature has been developed. This method offers a chemoselective, one-pot cascade access to δ-keto α-cyano esters with moderate to good yields under mild conditions.
The Michael addition of active methylene compounds to chalcone derivatives using a catalytic amount of iodine and K2CO3 at room temperature
Ren, Yi-Ming,Cai, Chun
experimental part, p. 176 - 178 (2011/07/31)
A convenient method for the Michael addition of active methylene compounds to chalcone derivatives has been developed using the inexpensive and environmentally friendly reagent I2/K2CO3 at room temperature. The method is m
Samarium(III) iodide promoted three-component coupling reactions of aldehydes, α-haloketones, and active methylene or methyl compounds
Ma, Yongmin,Zhang, Yongmin
, p. 711 - 715 (2007/10/03)
In the presence of samarium(III) iodide, the reaction of aldehydes, α-haloketones with malononitrile, ethylcyanoacetate or nitromethane proceeded very efficiently and furnished moderate to high yields of adducts.
A novel tandem reaction of chalcone with malononitrile or ethylcyanoacetate promoted by samarium (III) iodide and followed by samarium (II) iodide
Ma, Yongmin,Zhang, Yongmin
, p. 288 - 290 (2007/10/03)
Michael additions of active methylene compounds (for example: malononitrile, ethylcyanoacetate) to chalcones promoted by Sm3 gave 1,4-adducts which, after intramolecular coupling reactions induced by Sm2, furnished fine yields of cyc
New aspects of Michael reaction: Reaction of 1,3-diarylpropenones with active cyano compounds
El-Sadany, S K,Sharaf, S M,Darwish, A I,Youssef, A A
, p. 567 - 573 (2007/10/02)
Ethyl 2-cyano-5-oxo-3,5-diarylpentanoates (7a-k) and 1,3,5-triaryl-2-aroyl-4-cyano-4-carboethoxycyclohexanols (6a-e,g,i,k) are obtained when the corresponding 1,3-diarylpropenones (1a-k) are reacted with ethyl cyanoacetate in the presence of different ratios of ethoxide ion.The cyclic products (6) are also obtained by treating the corresponding mono-condensation products (7) with sodium ethoxide.Furthermore, 3-aryl-4-benzoyl-2-phenylbutyronitriles (8) are obtained from the reaction of 1 with benzylcyanide in equimolar amounts in the presence of sodium ethoxide. 2-Benzoyl-4-cyano-1,3,4,5-tetraphenylcyclohexanol (9) is however, obtained when two moles of 1a are treated with one mole of benzylcyanide in the presence of ethoxide ion.The mono-condensation product 8 when treated with sodium ethoxide does not give 9.The cyclohexanol compound 11a is also obtained by the reaction of 1a with malononitrile.The structures of all the compounds have been established by elemental analysis and spectral data (IR, UV, 1H NMR and 13C NMR).
