135885-89-1Relevant academic research and scientific papers
A mild, chemoselective, one-pot synthesis of δ-keto α-cyano esters by organocatalysis
Liu, Gang,Wang, Yingcai
, p. 189 - 192 (2014/01/06)
A sequential condensation of α-cyano esters, aldehydes, and ketones with catalytic amount of pyrrolidine/HOAc at room temperature has been developed. This method offers a chemoselective, one-pot cascade access to δ-keto α-cyano esters with moderate to good yields under mild conditions.
Ionic-liquid-supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene - An efficient and recyclable organocatalyst for Michael addition to α,β-unsaturated ketones
Muthyala, Manoj Kumar,Chhikara, Bhupender S.,Parang, Keykavous,Kumar, Anil
experimental part, p. 290 - 297 (2012/04/23)
A novel ionic-liquid-supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene (IL-TBD) was synthesized and investigated for its ability to act as an active organocatalyst in the Michael addition of active methylene compounds and thiophenols to chalcones under solven
New aspects of Michael reaction: Reaction of 1,3-diarylpropenones with active cyano compounds
El-Sadany, S K,Sharaf, S M,Darwish, A I,Youssef, A A
, p. 567 - 573 (2007/10/02)
Ethyl 2-cyano-5-oxo-3,5-diarylpentanoates (7a-k) and 1,3,5-triaryl-2-aroyl-4-cyano-4-carboethoxycyclohexanols (6a-e,g,i,k) are obtained when the corresponding 1,3-diarylpropenones (1a-k) are reacted with ethyl cyanoacetate in the presence of different ratios of ethoxide ion.The cyclic products (6) are also obtained by treating the corresponding mono-condensation products (7) with sodium ethoxide.Furthermore, 3-aryl-4-benzoyl-2-phenylbutyronitriles (8) are obtained from the reaction of 1 with benzylcyanide in equimolar amounts in the presence of sodium ethoxide. 2-Benzoyl-4-cyano-1,3,4,5-tetraphenylcyclohexanol (9) is however, obtained when two moles of 1a are treated with one mole of benzylcyanide in the presence of ethoxide ion.The mono-condensation product 8 when treated with sodium ethoxide does not give 9.The cyclohexanol compound 11a is also obtained by the reaction of 1a with malononitrile.The structures of all the compounds have been established by elemental analysis and spectral data (IR, UV, 1H NMR and 13C NMR).
