135900-33-3

Basic information

• Product Name: 6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE
• Synonyms: 6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE;6-(trifluoroMethoxy)pyridin-3-aMine;3-PyridinaMine, 6-(trifluoroMethoxy)-
• CAS NO: 135900-33-3
• Molecular Formula: C₆H₅F₃N₂O
• Molecular Weight: 178.1119096
• Mol File: 135900-33-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 31-33 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 203.3°C at 760 mmHg
• Flash Point: 76.8°C
• Appearance: /
• Density: 1.421g/cm³
• Vapor Pressure: 0.279mmHg at 25°C
• Refractive Index: 1.481
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.72±0.10(Predicted)
• CAS DataBase Reference: 6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE(135900-33-3)
• EPA Substance Registry System: 6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE(135900-33-3)

Safety Data

• Hazardous Substances Data: 135900-33-3(Hazardous Substances Data)

Usage

General Description

6-Trifluoromethoxy-pyridin-3-ylamine is a chemical compound with the molecular formula C6H5F3N2O. It is a heterocyclic amine containing a pyridine ring substituted with a trifluoromethoxy group at the 6 position. 6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is known for its ability to act as a versatile nucleophile and a strong base, making it valuable in various synthetic processes. Additionally, the trifluoromethoxy group provides unique chemical and physical properties to the molecule, making it of interest in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C6H5F3N2O/c7-6(8,9)12-5-2-1-4(10)3-11-5/h1-3H,10H2

Upstream product

• 1221172-05-9 3-amino-2-chloro-6-(trifluoromethoxy)pyridine 
• 1221172-07-1 C₉H₁₂ClF₃N₂OSi 
• 1221172-06-0 C₉H₁₀ClF₃N₄OSi 
• 1221172-02-6 2-chloro-6-(trifluoromethoxy)-5-(trimethylsilyl)pyridine 
• 1221171-70-5 2-chloro-6-(trifluoromethoxy)pyridine 

Relevant articles and documents

ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF

The present application is related to compounds represented by Formula I, which are novel positive allosteric modulators of α7 nAChRs. The application also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on α7 nAChRs in a mammal by administering an effective amount of a compound of Formula I.

A general approach to (trifluoromethoxy)pyridines: First X-ray structure determinations and quantum chemistry studies

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies. A general and efficient route to (trifluoromethoxy)pyridines is reported. Regioselective functionalization by organometallic methods afforded new and highly important building blocks for life-sciences-oriented research. The first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed and supported by in silico studies.