1359101-29-3Relevant academic research and scientific papers
Microwave-assisted synthesis, hypolipidemic and hypoglycemic activity of some novel 2-(4-(2-amino-6-(4-substituted phenyl)-pyrimidin-4-yl)-phenoxy)-2- methyl propanoic acid derivatives
Mokale, Santosh N.,Elgire, Rupali D.,Sakle, Nikhil S.,Shinde, Devanand B.
, p. 22 - 27 (2012/03/10)
A novel series of aminopyrimidines containing the phenoxy isobutyric acid group as a pharmacophore was synthesized using conventional and microwave assisted methods of synthesis. The compounds were synthesized in good yields (70-89%) by the microwave-assisted one-pot protocol in much shorter reaction times. The synthesized compounds were evaluated for their hypolipidemic and hypoglycemic activity by high-fat diet-induced hyperlipidemia and hyperglycemia in male Sprague-Dawley rats. The present investigation showed significant antihyperlipidemic and antihyperglycemic activity for all compounds of the series when compared with the standard drug. Structure-activity relationship (SAR) for the series were developed by comparing total lipid profile data of synthesized compounds with fenofibrate as standard drug. A novel series of aminopyrimidines containing the phenoxy isobutyric acid group as a pharmacophore was synthesized using conventional and microwave-assisted methods of synthesis. The synthesized compounds were evaluated for their hypolipidemic and hypoglycemic activities on high-fat diet-induced hyperlipidemia and hyperglycemia in male Sprague-Dawley rats. Copyright
