1359164-11-6

Basic information

• Product Name: 2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol
• Synonyms: 2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol;SR-2211;2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol (SR 2211)
• CAS NO: 1359164-11-6
• Molecular Formula: C26H24F7N3O
• Molecular Weight: 527.4770824
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1359164-11-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 552.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.358±0.06 g/cm3(Predicted)
• PKA: 8.85±0.19(Predicted)
• CAS DataBase Reference: 2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol(1359164-11-6)
• EPA Substance Registry System: 2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol(1359164-11-6)

Safety Data

• Hazardous Substances Data: 1359164-11-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1359164-11-6 differently. You can refer to the following data:
1. 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol was identified as a potent synthetic RORγ-selective modulator.
2. 2-Fluoro-4''-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-[1,1''-biphenyl]-4-methanol was identified as a potent synthetic RORγ-selective modulator.

Upstream product

• 138500-85-3 4-bromomethylphenylboronic acid pinacol ester 
• 1355338-16-7 2-(4-amino-3-fluorophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 348-54-9 2-Fluoroaniline 
• 62089-74-1 1-(pyridin-4-ylmethyl)piperazine 

Relevant articles and documents

Modulators of the nuclear hormone receptor ROR

The invention provides small molecule modulators of retinoic acid receptor-related orphan receptors such as RORα, RORβ, or RORγ, of formula with the variable atoms as defined herein and R1 comprising a hydroxyl- or alkoxyl-substituted fluoroalkyl group. Compounds of the invention can be effective modulators at concentrations ineffective to act on LXR receptors, or on other nuclear receptors, or other biological targets. Methods of modulation the RORs and methods of treating metabolic disorders, immune disorders, cancer, and CNS disorders wherein modulation of an ROR is medically indicated are also provided.