62089-74-1

Basic information

• Product Name: 1-(4-PYRIDYLMETHYL)PIPERAZINE
• Synonyms: AKOS B004019;AKOS BBS-00002872;(4-PYRIDYLMETHYL)PIPERAZINE;1-PYRIDIN-4-YLMETHYL-PIPERAZINE;1-(4-PYRIDYLMETHYL)PIPERAZINE;1-(4-PYRIDINYLMETHYL)PIPERAZINE;ART-CHEM-BB B004019;BUTTPARK 82\12-10
• CAS NO: 62089-74-1
• Molecular Formula: C₁₀H₁₅N₃
• Molecular Weight: 177.25
• Product Categories: PIPERIDINE;Amines and Anilines;Heterocycles;API intermediates;piperazines
• Mol File: 62089-74-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 68°C 0,15mm
• Flash Point: 135.3 °C
• Appearance: /
• Density: 1.073
• Vapor Pressure: 0.00114mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.01±0.10(Predicted)
• CAS DataBase Reference: 1-(4-PYRIDYLMETHYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-PYRIDYLMETHYL)PIPERAZINE(62089-74-1)
• EPA Substance Registry System: 1-(4-PYRIDYLMETHYL)PIPERAZINE(62089-74-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 62089-74-1(Hazardous Substances Data)

Usage

General Description

1-(4-Pyridylmethyl)piperazine, also known as piperazine, is a chemical compound with the molecular formula C11H16N2. It is commonly used as a building block in the synthesis of various pharmaceutical drugs, particularly antipsychotic and antihistamine medications. Piperazine acts as a serotonin receptor antagonist and is also used as an industrial chemical in the production of plastics, resins, and rubber additives. It has been studied for its potential as a drug for the treatment of depression, anxiety, and other mental health disorders. However, it is important to note that piperazine can be toxic in high doses and should be handled and used with caution.

InChI:InChI=1/C10H15N3/c1-3-11-4-2-10(1)9-13-7-5-12-6-8-13/h1-4,12H,5-9H2

Upstream product

• 120-43-4 4-ethoxycarbonylpiperazine 
• 143210-48-4 4-(4-pyridylmethyl)-1-piperazinecarboxylic acid, ethyl ester 
• 67-63-0 isopropyl alcohol 
• 54751-01-8 4-(bromomethyl)pyridine 
• 150812-38-7 tert-butyl 4-(pyridin-4-ylmethyl)piperazine-1-carboxylate 
• 872-85-5 pyridine-4-carbaldehyde 
• 10445-91-7 4-(Chloromethyl)pyridine 
• 942486-74-0 C₁₂H₁₇N₃O 

Downstream Products

• 1277167-60-8 C₂₀H₂₀ClN₅O 
• 1359164-11-6 SR2211 
• 1400691-89-5 N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-[4-(4-pyridinylmethyl)-1-piperazinyl]-1H-1,2,4-triazol-5-amine 
• 1400692-03-6 C₁₈H₁₉N₅O 
• 1260629-35-3 C₂₈H₃₈ClN₅O₂ 
• 1268619-08-4 C₄₉H₅₈N₈O₉S₃ 
• 1258411-05-0 C₂₅H₂₆ClN₉OS 

Relevant articles and documents

Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer

Poly (ADP-ribose) polymerase-1 (PARP-1) is a potential target for the discovery of chemosensitizers and anticancer drugs. Amentoflavone (AMF) is reported to be a selective PARP-1 inhibitor. Here, structural modifications and trimming of AMF have led to a series of AMF derivatives (9a-h) and apigenin-piperazine/piperidine hybrids (14a-p, 15a-p, 17a-h, and 19a-f), respectively. Among these compounds, 15l exhibited a potent PARP-1 inhibitory effect (IC50 = 14.7 nM) and possessed high selectivity to PARP-1 over PARP-2 (61.2-fold). Molecular dynamics simulation and the cellular thermal shift assay revealed that 15l directly bound to the PARP-1 structure. In in vitro and in vivo studies, 15l showed a potent chemotherapy sensitizing effect against A549 cells and a selective cytotoxic effect toward SK-OV-3 cells through PARP-1 inhibition. 15l·2HCl also displayed good ADME characteristics, pharmacokinetic parameters, and a desirable safety margin. These findings demonstrated that 15l·2HCl may serve as a lead compound for chemosensitizers and the (BRCA-1)-deficient cancer therapy.

Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors

A series of novel 1,4-disubstituted piperidine/piperazine derivatives were designed, synthesized and evaluated for their in vitro activities against HIV-1 Bal (R5) infection in CEMX174 5.25M7 cells. A majority of these compounds showed potent anti-HIV-1 activities with IC50 at nanomolar levels. N-(4-Fluoro-benzyl)piperazine analog B07 hydrochloride exhibited potency against HIV-1 activity similar to that of TAK-220 hydrochloride, but it had much better water solubility (25 mg/ml in phosphate sodium buffer at 25 °C) and oral bioavailability (56%) than TAK-220 hydrochloride (a solubility of 2 mg/ml and oral bioavailability of 1.4%). These results suggest that B07 hydrochloride may serve as a better lead for the development of new anti-HIV-1 therapies or microbicides for treatment and prevent of HIV-1 infection.

TRIAZOLE DERIVATIVES HAVING ANTIFUNGAL ACTIVITY, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

A triazole derivative of formula 1 or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof is superior to the conventional antifungal drugs in antifungal activity against a wide spectrum of pathogenic fungi, and has advantageously low toxicity.