135941-84-3

Basic information

• Product Name: Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt
• Synonyms: DicyclohexylaMine (S)-2-((tert-butoxycarbonyl)aMino)-4-Methoxy-4-oxobutanoate;N-[(1,1-Dimethylethoxy)carbonyl]-L-aspartic acid 4-methyl ester compd. With N-cyclohexylcyclohexanamine;(Tert-Butoxy)Carbonyl Asp(OMe)-OH·DCHA
• CAS NO: 135941-84-3
• Molecular Formula: C₁₀H₁₇NO₆*C₁₂H₂₃N
• Molecular Weight: 428.5628
• EINECS: -0
• Product Categories: Boc-Amino acids
• Mol File: 135941-84-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt(135941-84-3)
• EPA Substance Registry System: Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt(135941-84-3)

Safety Data

• Hazardous Substances Data: 135941-84-3(Hazardous Substances Data)

Usage

Description

Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt, also known as Dicyclohexylamine (S)-2-((tert-butoxycarbonyl)-amino)-4-methoxy-4-oxobutanoate, is a chemical compound derived from Boc-L-aspartic acid. It is characterized by its unique molecular structure, which includes a Boc-protected aspartic acid backbone and a 4-methyl ester group. Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt is a valuable intermediate in the synthesis of various pharmaceutical compounds and has potential applications in the development of new drugs.

Uses

Used in Pharmaceutical Industry:
Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt is used as a key intermediate in the synthesis of isoxazoline glycoprotein IIb/IIIa antagonists. These antagonists are important in the development of antiplatelet drugs, which are crucial for the treatment of various cardiovascular diseases, such as acute coronary syndrome, myocardial infarction, and stroke.
Additionally, Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt is used as a starting material for the synthesis of glutamic acid analogs. These analogs have been identified as potent inhibitors of leukotriene A4 hydrolase (LTA4H), an enzyme involved in the production of leukotrienes, which are inflammatory mediators. Inhibiting LTA4H can help in the development of anti-inflammatory drugs for the treatment of conditions such as asthma, rheumatoid arthritis, and inflammatory bowel disease.

Upstream product

• 67-56-1 methanol 
• 56-84-8 L-Aspartic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 101-83-7 N-cyclohexyl-cyclohexanamine 

Downstream Products

• 40856-59-5 tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate 

Relevant articles and documents

Improved synthesis of L-homoserine derivatives from L-aspartic acid

N-Alkoxycarbonyl-L-homoserine lactones (α-alkoxycarbonyl-amino-γ-butyrolactones) were prepared by selective esterification of L-aspartatic acid followed by N-protection, precipitation of the dicyclohexylammonium salts, chemoselective reduction with lithium borohydride, and cyclization to the corresponding γ-lactones during isolation.