Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt

Base Information

• Chemical Name: Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt
• CAS No.: 135941-84-3
• Molecular Formula: C12H23N.C10H17NO6
• Molecular Weight: 428.569
• Hs Code.: 2924299090
• Mol file: 135941-84-3.mol

Synonyms:Dicyclohexylamine (S)-2-((tert-butoxycarbonyl)amino)-4-methoxy-4-oxobutanoate;4-methyl (S)-N-tert-butoxycarbonylaspartate dicyclohexylammonium salt;Boc-Asp(OMe)-OH*DCHA;

Chemical Property of Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt

Chemical Property:

• PSA: 113.96000
• LogP: 4.55060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Dicyclohexylamine (S)-2-((tert-butoxycarbonyl)-amino)-4-methoxy-4-oxobutanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dicyclohexylamine (S)-2-((tert-butoxycarbonyl)-amino)-4-methoxy-4-oxobutanoate is used to prepare isoxazoline glycoprotein IIb/IIIa antagonists. It is also used to synthesize glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase

Technology Process of Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt

There total 1 articles about Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + L-Aspartic acid (56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) + di-tert-butyl dicarbonate (24424-99-5) + N-cyclohexyl-cyclohexanamine (101-83-7) → 4-methyl (S)-N-tert-butoxycarbonylaspartate dicyclohexylammonium salt (135941-84-3)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1055/s-1991-26507

Reference yield:

4-methyl (S)-N-tert-butoxycarbonylaspartate dicyclohexylammonium salt (135941-84-3) → tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate (40856-59-5,132957-40-5)

Guidance literature:

With sodium tetrahydroborate; sulfuric acid; lithium bromide; Yield given. Multistep reaction; 1) diglyme, 110 deg C, 24 h, 2) 0 deg C to 40 deg C, water, CH₂Cl₂;

DOI:10.1055/s-1991-26507

upstream raw materials:

methanol

L-Aspartic acid

di-tert-butyl dicarbonate

N-cyclohexyl-cyclohexanamine

Downstream raw materials:

tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate

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