1359857-70-7

Basic information

• Product Name: C₁₈H₂₅BO₇
• Synonyms: C₁₈H₂₅BO₇
• CAS NO: 1359857-70-7
• Molecular Weight: 364.203
• Mol File: 1359857-70-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₅BO₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₅BO₇(1359857-70-7)
• EPA Substance Registry System: C₁₈H₂₅BO₇(1359857-70-7)

Safety Data

• Hazardous Substances Data: 1359857-70-7(Hazardous Substances Data)

Upstream product

• 1422-53-3 2-bromo-4-fluorotoluene 
• 1359857-66-1 C₁₀H₉BrO₄ 
• 1359857-64-9 C₉H₆Br₃FO₂ 
• 1359857-62-7 2-bromo-6-fluoro-3-methylbenzoic acid methyl ester 
• 1359857-60-5 2-bromo-6-fluoro-3-methylbenzoic acid 
• 154650-16-5 2-bromo-6-fluoro-3-methylbenzaldehyde 
• 1359857-68-3 C₁₂H₁₃BrO₅ 
• 73183-34-3 bis(pinacol)diborane 

Relevant articles and documents

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

A series of new boron-containing benzoxaborole compounds was designed and synthesized for a continuing structure-activity relationship (SAR) investigation to assess the antimalarial activity changes derived from side-chain structural variation, substituent modification on the benzene ring and removal of boron from five-membered oxaborole ring. This SAR study demonstrated that boron is required for the antimalarial activity, and discovered that three fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles (9, 14 and 20) have excellent potencies (IC50 0.026-0.209 μM) against Plasmodium falciparum.