C₁₈H₂₅BO₇

Base Information

• Chemical Name: C₁₈H₂₅BO₇
• CAS No.: 1359857-70-7
• Molecular Formula: C₁₈H₂₅BO₇
• Molecular Weight: 364.203
• Mol file: 1359857-70-7.mol

Synonyms:C₁₈H₂₅BO₇

Chemical Property of C₁₈H₂₅BO₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₅BO₇

There total 7 articles about C₁₈H₂₅BO₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C12H13BrO5 (1359857-68-3) + bis(pinacol)diborane (73183-34-3) → C18H25BO7 (1359857-70-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In 1,4-dioxane; at 95 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.12.096

Reference yield:

2-bromo-6-fluoro-3-methylbenzaldehyde (154650-16-5) → C18H25BO7 (1359857-70-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 1 h / 20 °C

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Inert atmosphere; Reflux

4.1: methanol / 4 h / 65 °C

4.2: pH 2

5.1: pyridinium p-toluenesulfonate / toluene / 16 h / Reflux

6.1: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / 1,4-dioxane / 16 h / 95 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; N-Bromosuccinimide; 2-methyl-but-2-ene; sodium dihydrogenphosphate dihydrate; potassium acetate; pyridinium p-toluenesulfonate; potassium carbonate; dibenzoyl peroxide; In 1,4-dioxane; methanol; tetrachloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2011.12.096

Reference yield:

2-bromo-6-fluoro-3-methylbenzoic acid methyl ester (1359857-62-7) → C18H25BO7 (1359857-70-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Inert atmosphere; Reflux

2.1: methanol / 4 h / 65 °C

2.2: pH 2

3.1: pyridinium p-toluenesulfonate / toluene / 16 h / Reflux

4.1: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / 1,4-dioxane / 16 h / 95 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; potassium acetate; pyridinium p-toluenesulfonate; dibenzoyl peroxide; In 1,4-dioxane; methanol; tetrachloromethane; toluene;

DOI:10.1016/j.bmcl.2011.12.096

upstream raw materials:

C₁₂H₁₃BrO₅

bis(pinacol)diborane

2-bromo-6-fluoro-3-methylbenzaldehyde

2-bromo-6-fluoro-3-methylbenzoic acid