1359948-56-3

Basic information

• Product Name: C₄₀H₇₃BrO₉Si₅
• Synonyms: C₄₀H₇₃BrO₉Si₅
• CAS NO: 1359948-56-3
• Molecular Weight: 918.346
• Mol File: 1359948-56-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₄₀H₇₃BrO₉Si₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₀H₇₃BrO₉Si₅(1359948-56-3)
• EPA Substance Registry System: C₄₀H₇₃BrO₉Si₅(1359948-56-3)

Safety Data

• Hazardous Substances Data: 1359948-56-3(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 1240304-54-4 1,5-dibromo-2-(methoxymethoxy)-4-(propan-2-yl)benzene 
• 24078-12-4 4-bromo-2-methylbenzaldehyde 
• 32469-28-6 (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one 
• 618-45-1 3-isopropylhydroxybenzene 
• 16606-30-7 2,4-dibromo-5-isopropylphenol 

Downstream Products

• 1359948-57-4 C₂₄H₃₁BrO₈ 
• 1359948-58-5 C₃₆H₄₃BrO₁₄ 
• 1240304-31-7 (1S)-2,3,4,6-tetra-O-acetyl-1-[2-(acetyloxy)-5-[(4-bromo-2-methylphenyl)methyl]-4-(propan-2-yl)phenyl]-1,5-anhydro-D-glucitol 
• 1369430-79-4 C₃₉H₄₈O₁₃ 
• 1369430-81-8 C₃₇H₅₅N₃O₈ 
• 1369430-92-1 C₃₇H₅₅N₃O₈ 
• 1369430-76-1 C₄₃H₅₅NO₁₄ 
• 1369430-91-0 C₄₇H₆₅N₃O₁₃ 
• 1369430-80-7 C₄₇H₆₅N₃O₁₃ 
• 1369430-89-6 C₅₀H₆₉N₃O₁₃ 
• 1369430-93-2 C₅₂H₇₃N₃O₁₅ 
• 1240304-62-4 (1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-{5-[(4-bromo-2-methylphenyl)methyl]-2-methoxy-4-(propan-2-yl)phenyl}-D-glucitol 

Relevant articles and documents

Synthesis and structure-activity relationship of C-phenyl D-glucitol (TP0454614) derivatives as selective sodium-dependent glucose cotransporter 1 (SGLT1) inhibitors

Sodium-glucose cotransporter 1 (SGLT1) is the primary transporter for glucose absorption from the gastrointestinal tract. While C-phenyl D-glucitol derivative SGL5213 has been reported to be a potent intestinal SGLT1 inhibitor for use in the treatment of type 2 diabetes, no SGLT1 selectivity was found in vitro (IC50 29 nM for hSGLT1 and 20 nM for hSGLT2). In this study we found a new method of synthesizing key intermediates 12 by a one-pot three-component condensation reaction and discovered C-phenyl D-glucitol 41j (TP0454614), which has >40-fold SGLT1 selectivity in vitro (IC50 26 nM for hSGLT1 and 1101 nM for hSGLT2). The results of our study have provided new insights into the structure-activity relationships (SARs) of the SGLT1 selectivity of C-glucitol derivatives.