1359969-70-2

Upstream product

• 21691-53-2 L-leucine tert-butyl ester 
• 1359969-60-0 (S)-tert-butyl 2-((S)-6-azido-2-(((benzyloxy)carbonyl)amino)hexanamido)-4-methylpentanoate 

Downstream Products

• 1359969-79-1 benzyl ((S)-6-azido-1-(((S)-1-(((S)-1-hydroxy-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxohexan-2-yl)carbamate 
• 1359969-89-3 benzyl N-[(12S,15S,18S)-18-(hydroxymethyl)-15-(2-methylpropyl)-13,16-dioxo-2-oxa-5,6,7,14,17-pentaazatricyclo[18.2.2.1(4,7)]pentacosa-1⁽²²⁾,4⁽²⁵⁾,5,20,23-pentaen-12-yl]carbamate 
• 1359969-98-4 benzyl ((S)-6-azido-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)pentan-2-yl)amino)-1-oxohexan-2-yl)carbamate 
• 1359969-05-3 benzyl N-[(12S,15S,18S)-18-formyl-15-(2-methylpropyl)-13,16-dioxo-2-oxa-5,6,7,14,17-pentaazatricyclo[18.2.2.1(4,7)]pentacosa-1⁽²²⁾,4⁽²⁵⁾,5,20,23-pentaen-12-yl]carbamate 
• 1417159-45-5 methyl (6S,9S,12S)-6-(((benzyloxy)carbonyl)amino)-9-isobutyl-7,10-dioxo-1,8,11,15,16-pentaazabicyclo[12.2.1]heptadeca-14⁽¹⁷⁾,15-diene-12-carboxylate 
• 1417159-46-6 benzyl ((6S,9S,12S)-12-(hydroxymethyl)-9-isobutyl-7,10-dioxo-1,8,11,15,16-pentaazabicyclo[12.2.1]heptadeca-14⁽¹⁷⁾,15-dien-6-yl)carbamate 
• 1417159-47-7 benzyl ((6S,9S,12S)-12-formyl-9-isobutyl-7,10-dioxo-1,8,11,15,16-pentaazabicyclo[12.2.1]heptadeca-14⁽¹⁷⁾,15-dien-6-yl)carbamate 
• 1417159-48-8 methyl (6S,9S,12S)-6-(((benzyloxy)carbonyl)amino)-9-isobutyl-7,10-dioxo-14-oxa-1,8,11,17,18-pentaazabicyclo[14.2.1]nonadeca-16⁽¹⁹⁾,17-diene-12-carboxylate 
• 1417159-49-9 benzyl ((6S,9S,12R)-12-(hydroxymethyl)-9-isobutyl-7,10-dioxo-14-oxa-1,8,11,17,18-pentaazabicyclo[14.2.1]nonadeca-16⁽¹⁹⁾,17-dien-6-yl)carbamate 
• 1417159-50-2 benzyl ((6S,9S,12S)-12-formyl-9-isobutyl-7,10-dioxo-14-oxa-1,8,11,17,18-pentaazabicyclo[14.2.1]nonadeca-16⁽¹⁹⁾,17-dien-6-yl)carbamate 
• 1417159-42-2 methyl (5S,8S,11S)-5-(4-azidobutyl)-8-isobutyl-3,6,9-trioxo-1-phenyl-11-(prop-2-yn-1-yl)-2-oxa-4,7,10-triazadodecan-12-oate 
• 1417159-44-4 methyl (5S,8S,11S)-5-(4-azidobutyl)-8-isobutyl-3,6,9-trioxo-1-phenyl-11-((prop-2-yn-1-yloxy)methyl)-2-oxa-4,7,10-triazadodecan-12-oate 

Relevant academic research and scientific papers

New β-strand templates constrained by Huisgen cycloaddition

New peptidic templates constrained into a β-strand geometry by linking acetylene and azide containing P1 and P3 residues of a tripeptide by Huisgen cycloaddition are presented. The conformations of the macrocycles are defined by NMR studies and those that best define a β-strand are shown to be potent inhibitors of the protease calpain. The β-strand templates presented and defined here are prepared under optimized conditions that should be suitable for targeting a range of proteases and other applications requiring such a geometry.