1359969-86-0

Upstream product

• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 3978-80-1 Boc-Tyr-OH 
• 21691-53-2 L-leucine tert-butyl ester 
• 1359969-76-8 benzyl ((S)-5-azido-1-(((S)-1-(((S)-1-hydroxy-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate 
• 1359969-66-6 (S)-2-((S)-5-azido-2-(((benzyloxy)carbonyl)amino)pentanamido)-4-methylpentanoic acid 
• 1359969-57-5 (S)-tert-butyl 2-((S)-5-azido-2-(((benzyloxy)carbonyl)amino)pentanamido)-4-methylpentanoate 
• 1359969-17-7 (S)-2-amino-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-1-ol 
• 1044548-57-3 C₁₃H₁₅NO₃ 
• 949894-57-9 (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl) propanoate 
• 1001646-61-2 5-azido-2-(((benzyloxy)carbonyl)amino)pentanoic acid 

Downstream Products

• 1359969-02-0 benzyl N-[(11S,14S,17S)-17-formyl-14-(2-methylpropyl)-12,15-dioxo-2-oxa-5,6,7,13,16-pentaazatricyclo[17.2.2.1(4,7)]tetracosa-1⁽²¹⁾,4⁽²⁴⁾,5,19,22-pentaen-11-yl]carbamate 

Relevant academic research and scientific papers

MACROCYCLIC COMPOUNDS AND USES THEREOF

The present invention relates to novel macrocyclic compounds of Formula I and their use as novel therapeutic agents for example as novel compounds used in methods of preventing and/or treating a disease, condition or state in a subject associated with dysregulation of protease activity and/or dysregulation of proteosome activity

New β-strand templates constrained by Huisgen cycloaddition

New peptidic templates constrained into a β-strand geometry by linking acetylene and azide containing P1 and P3 residues of a tripeptide by Huisgen cycloaddition are presented. The conformations of the macrocycles are defined by NMR studies and those that best define a β-strand are shown to be potent inhibitors of the protease calpain. The β-strand templates presented and defined here are prepared under optimized conditions that should be suitable for targeting a range of proteases and other applications requiring such a geometry.