1359976-91-2

Upstream product

• 52085-14-0 4-benzoxy-salicylaldehyde 
• 105983-77-5 methyl 4-bromo-3-oxopentanoate 
• 103788-64-3 methyl 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetate 
• 55-21-0 benzamide 
• 24534-37-0 6-hydroxy-2-phenylbenzofuran 
• 227029-27-8 2-(2-phenyl-5-methyloxazole-4-yl)ethyl methanesulfonate 
• 24534-38-1 6-(benzyloxy)-2-(phenyl)benzofuran 

Downstream Products

• 1359977-07-3 6-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2-phenylbenzofuran-3-carbaldehyde 

Relevant academic research and scientific papers

Synthesis and antimicrobial evaluation of 3-methanone-6-substituted- benzofuran derivatives

Seventeen benzofuran derivatives were synthesized and screened for their antibacterial activities against Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Seven of them have showed excellent antibacterial activities compared to the positive controls (Cefotaxime and Sodium Penicillin). The substitutions at C-6 and C-3 positions of these derivatives were found to greatly impact on the antibacterial activity and strains specificity, respectively. Specifically, compounds bearing a hydroxyl group at C-6 (5a, 5b, 5c and 12) offered excellent antibacterial activities against all five above-mentioned strains (MIC 80 = 0.78-12.5 ug/mL), and those with imine (15) and (3, 4, 5-trimethoxyphenyl) methanone (7e), respectively, at C-3 position showed selective activity against S. aureus among five tested strains with great MIC80 values (3.12-12.5 ug/mL).