103788-64-3

Basic information

• Product Name: METHYL 2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETATE
• Synonyms: METHYL 2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETATE;BUTTPARK 37\06-79;Methyl 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)-;METHYL (5-METHYL-2-PHENYLOXAZOL-4-YL)ACETATE;Methyl-2-(5-methyl-2-phenyloxazol-4-yl)acetate;(5-Methyl-2-phenyloxazol-4-yl)acetic acid methyl ester;2-[5-Methyl-2-phenyl-1,3-oxazol-4-yl]acetic acid Methyl ester;Methyl (5-methyl-2-phenyl-1,3-oxazol-4-yl)acetate
• CAS NO: 103788-64-3
• Molecular Formula: C₁₃H₁₃NO₃
• Molecular Weight: 231.25
• Mol File: 103788-64-3.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 357.3 °C at 760 mmHg
• Flash Point: 169.9 °C
• Appearance: /
• Density: 1.157
• Vapor Pressure: 2.75E-05mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: 2-8°C
• PKA: 0.37±0.26(Predicted)
• CAS DataBase Reference: METHYL 2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETATE(103788-64-3)
• EPA Substance Registry System: METHYL 2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETATE(103788-64-3)

Safety Data

• Hazardous Substances Data: 103788-64-3(Hazardous Substances Data)

Usage

General Description

METHYL 2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETATE is a chemical compound with the molecular formula C13H13NO3. It is an ester, specifically the methyl ester of 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetic acid. METHYL 2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETATE is commonly used as a fragrance ingredient in perfumes and other scented products due to its pleasant odor. It is also utilized in the manufacturing of pharmaceuticals and other organic compounds. Additionally, it has potential applications in the field of organic synthesis and medicinal chemistry.

InChI:InChI=1/C13H13NO3/c1-9-11(8-12(15)16-2)14-13(17-9)10-6-4-3-5-7-10/h3-7H,8H2,1-2H3

Upstream product

• 54819-26-0 methyl 3-(benzoylamino)-4-oxovalerate 
• 55-21-0 benzamide 
• 105983-77-5 methyl 4-bromo-3-oxopentanoate 
• 30414-53-0 methyl propanoyl acetate 
• 67-56-1 methanol 
• 524959-64-6 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetonitrile 
• 98-88-4 benzoyl chloride 
• 39741-26-9 N-benzoyl-L-aspartic acid β-methyl ester 
• 100373-13-5 methyl 3-benzamido-4-oxovalerate 

Downstream Products

• 174258-60-7 1-{3-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-ethanone 
• 501028-44-0 2-(5-Methyl-2-phenyl-oxazol-4-yl)-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid 
• 501031-61-4 2-(5-methyl-2-phenyloxazol-4-yl)acetaldehyde 
• 1262547-45-4 (R)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate 
• 1262547-46-5 (S)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate 
• 1334871-98-5 (S)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-phenoxypropanoate 
• 1334872-00-2 (S)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-(pyridin-3-yloxy)propanoate 
• 1262547-50-1 (S)-methyl 2-(4-fluorophenoxy)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate 
• 1334872-05-7 (S)-methyl 2-(3-fluorophenoxy)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate 
• 1334872-07-9 (S)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-(3,4,5-trifluorophenoxy)propanoate 
• 1262547-51-2 (S)-methyl 2-(4-bromophenoxy)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate 
• 1334872-10-4 (S)-methyl 2-(2-bromophenoxy)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate 
• 1262547-52-3 (S)-methyl 2-(4-chlorophenoxy)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate 
• 1334872-13-7 (S)-methyl 2-(2,4-dichlorophenoxy)-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate 

Relevant articles and documents

Synthesis and antimicrobial evaluation of 3-methanone-6-substituted- benzofuran derivatives

Seventeen benzofuran derivatives were synthesized and screened for their antibacterial activities against Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Seven of them have showed excellent antibacterial activities compared to the positive controls (Cefotaxime and Sodium Penicillin). The substitutions at C-6 and C-3 positions of these derivatives were found to greatly impact on the antibacterial activity and strains specificity, respectively. Specifically, compounds bearing a hydroxyl group at C-6 (5a, 5b, 5c and 12) offered excellent antibacterial activities against all five above-mentioned strains (MIC 80 = 0.78-12.5 ug/mL), and those with imine (15) and (3, 4, 5-trimethoxyphenyl) methanone (7e), respectively, at C-3 position showed selective activity against S. aureus among five tested strains with great MIC80 values (3.12-12.5 ug/mL).

(S)-3-(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-(piperazin-1-yl)propanoic acid compounds: Synthesis and biological evaluation of dual PPARα/γ agonists

A series of novel, potent PPARα/γ dual agonists were synthesized and appraised. The most potent analogue, compound 2b demonstrated EC50 value of 0.012 ± 0.002 and 0.032 ± 0.01 μM, respectively, for hPPARα and hPPARγ in transactivation assay. Additionally, compound 2b demonstrated good glucose and lipid lowering effect in genetic diabetic (db/db) mice.

TYROSINE DERIVATIVES SUBSTITUTED BY N-PHENYLACRYLOYL AS AGONISTS OF HPPAR ALPHA AND HPPAR GAMA

The present invention relates to a compound of formula I, racemates, optically active isomers, or pharmaceutically acceptable salts or solvates thereof, and a pharmaceutical composition comprising the compound, the various radicals in the formula I are the same as defined in the claims. The present invention also relates to a process for preparing the compound of formula I and use of said compound in the preparation of a medicament for the treatment of hyperglycemia, dyslipidemia, type II diabetes mellitus including associated diabetic dyslipidemia