13600-33-4

Usage

Uses

Used in Pharmaceutical Industry:
Pyrimidine, 2-(1H-tetrazol-5-yl)(8CI,9CI) serves as a valuable building block for the synthesis of various pharmaceutical compounds. Its unique structure, which includes both a pyrimidine ring and a tetrazole group, contributes to its potential in creating novel drugs with improved therapeutic properties.
Used in Drug Development:
As an intermediate in drug development, Pyrimidine, 2-(1H-tetrazol-5-yl)(8CI,9CI) aids in the creation of new pharmaceutical agents. The bioactive nature of the tetrazole group, combined with the versatility of the pyrimidine ring, makes Pyrimidine, 2-(1H-tetrazol-5-yl)- (8CI,9CI) instrumental in the design and synthesis of innovative therapeutics.
Further research and development of Pyrimidine, 2-(1H-tetrazol-5-yl)(8CI,9CI) may lead to the discovery of novel drugs or therapeutic agents, particularly those targeting specific medical conditions or diseases. Its role in the pharmaceutical industry is thus multifaceted, encompassing both the synthesis of existing drugs and the exploration of new chemical entities for treatment.

Upstream product

• 14080-23-0 2-cyanopyrimidine 

Relevant academic research and scientific papers

Three new alkaline earth coordination compounds based on 5-(2-pyrimidyl)tetrazole-2-acetic acid

Reactions of Hpymtza (Hpymtza = 5-(2-pyrimidyl)tetrazole-2-acetic acid) with MCl2(M = Mg(II), Sr(II), Ba(II)), produced three new coordination compounds, [Mg(H2O)6]·2pymtza·H2O (1), [Sr(pymtza)2(H2O)2]·4H2O (2), [Ba(pymtza)2(H2O)4]·H2O (3), These compounds were characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Compound 1 shows a mononuclear structure while 2 and 3 reveal 1-D structures via bridging pymtza as linker. Furthermore, the luminescent properties of 1-3 were investigated at room temperature in the solid state.

Four structurally diverse coordination complexes based on a new flexible ligand

Four new coordination compounds, namely mononuclear [Zn(pyrtza) 2(H2O)2] (1), binuclear [Ni(pyrtza)(H 2O)2Cl]2 (2), 1D [Cd(pyrtza)2] (3), and 2D [Mn(pyrtza)Cl] (4), were synthesized by the reactions of Hpyrtza (Hpyrtza = 5-(2-pyrimidyl) tetrazole-2-acetic acid) with MCl2 (M = Zn(II), Ni(II), Cd(II), Mn(II)) in the presence of KOH under solvothermal conditions. The compounds were characterized by elemental analysis, IR spectroscopy, and single-crystal X-ray diffraction. The luminescence properties of the complexes were investigated at room temperature in the solid state. Graphical Abstract: Four new coordination compounds, namely mononuclear [Zn(pyrtza) 2(H2O)2] (1), binuclear [Ni(pyrtza) (H 2O)2Cl]2 (2), 1D [Cd(pyrtza)2] (3), and 2D [Mn(pyrtza)Cl] (4), were synthesized [Hpyrtza = 5-(2-pyrimidyl) tetrazole-2-acetic acid]. The luminescence properties of the complexes were investigated at room temperature in the solid state.[Figure not available: see fulltext.]

PH Dependent Synthesis of Two Manganese Compounds based on 5-(2-Pyrimidyl)tetrazole-1-acetic Acid

Reactions of Hpymtza [Hpymtza = 5-(2-pyrimidyl)tetrazole-1-acetic acid] with MnCl2·4H2O under different pH conditions, afforded the complexes [Mn(pymtza)2(H2O)4] (1) and [Mn2(pymtza)2Cl2(EtOH)]·H2O (2). The compounds were structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Compound 1 shows a mononuclear structure, whereas complex 2 has a 1D chain structure. In compound 1, the pymtza ligand only acts in a monodentate manner to coordinate to one central MnII atom by one carboxylate atom, In 2, pymtza acts as tetradentate ligand to connect three MnII ions. Compounds 1 and 2 display 3D networks by hydrogen bonding interactions. Furthermore, the luminescence properties of Hpymtza as well as compounds 1 and 2 were investigated at room temperature in the solid state.

MnII- and CoII-Catalyzed Transformation of 2-Cyanopyrimidine to Methylimidate by Sodium Azide: Isolation, Structural Characterization, and Magnetic Studies on 2D MnII- and CuII-Complexes

The MnII-mediated transformation of 2-cyanopyrimidine to methylimidate in the presence of inorganic azide is proven through isolation and structural characterization of a metal complex. Though the reaction conditions are favorable for a "click"

PROCESS FOR PREPARING 5-SUBSTITUTED-1H-TETRAZOLES IN AQUEOUS BETAINE SOLUTION

The present invention relates to a method for manufacturing 5-substituted-1H-tetrazole in an aqueous betaine solution. More specifically, the present invention relates to a method for manufacturing 5-substituted-1H-tetrazole which comprises: a step of con

The synthesis of tetrazoles in nanometer aqueous micelles at room temperature

A newly developed nonionic amphiphile (GPGS-1500), a diester composed of a Guerbet alcohol (2-octyldodecan-1-ol), poly(ethylene glycol) 1500 (PEG 1500), and succinic acid esters, has been prepared as an effective nanomicelle-forming species for the synthesis of tetrazoles in water at room temperature. We have designed a new nonionic amphiphile (GPGS-1500) for the synthesis of tetrazoles in water at room temperature. The reaction conditions were optimized, and the size of the micelles formed by GPGS-1500 in water was measured by dynamic light scattering. Copyright

The Synthesis of Tetrazoles in Nanometer Aqueous Micelles at Room Temperature

A newly developed nonionic amphiphile (GPGS-1500), a diester composed of a Guerbet alcohol (2-octyldodecan-1-ol), poly(ethylene glycol) 1500 (PEG 1500), and succinic acid esters, has been prepared as an effective nanomicelle-forming species for the synthesis of tetrazoles in water at room temperature.

Syntheses of Chelating Tetrazole-Containing Ligands and Studies of Their Palladium(II) and Ruthenium(II) Complexes

Eleven chelating tetrazole-containing ligands have been synthesized, and their complexes with palladium(II) and ruthenium(II) prepared.Proton n.m.r. spectroscopy, electronic absorption spectroscopy and cyclic voltammetry have been used to study the nature of the metal-ligand interactions in these complexes.The negatively charged tetrazolate group is shown to be a strong electron donor with very different properties to those of the protonated or alkylated tetrazole group.This leads to pH control of the properties of transition metal complexes containing such ligands.