1360109-87-0

Basic information

• Product Name: (5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
• Synonyms: (5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
• CAS NO: 1360109-87-0
• Molecular Weight: 408.654
• Mol File: 1360109-87-0.mol

Chemical Properties

• CAS DataBase Reference: (5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one(1360109-87-0)
• EPA Substance Registry System: (5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one(1360109-87-0)

Safety Data

• Hazardous Substances Data: 1360109-87-0(Hazardous Substances Data)

Upstream product

• 144735-54-6 1-ethynyl-4-(benzyloxy)-3-methoxybenzene 
• 35192-73-5 (S)-4-hydroxy-1-nonene 
• 66-25-1 hexanal 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 1360109-84-7 (S)-tert-butyldimethyl(non-1-en-4-yloxy)silane 
• 1360109-85-8 C₃₀H₄₄O₄Si 
• 1360109-86-9 (S)-1-(4-(benzyloxy)-3-methoxyphenyl)-5-(tert-butyldimethylsilyloxy)dec-1-yn-3-one 
• 69172-20-9 3-(3-methoxy-4-benzyloxyphenyl)propionaldehyde 
• 57371-44-5 3-<4-(benzyloxy)-3-methoxyphenyl>propan-1-ol 

Downstream Products

• 1360109-90-5 (4R,6S)-4-(4-(benzyloxy)-3-methoxyphenethyl)-2,2-dimethyl-6-pentyl-1,3-dioxane 
• 1360109-92-7 (3R,5S)-1-(4-(benzyloxy)-3-methoxyphenyl)decane-3,5-diol 
• 1360109-93-8 (3R,5S)-1-(4-(benzyloxy)-3-methoxyphenyl)decane-3,5-diyl diacetate 
• 1360109-91-6 (4R,6S)-4-(3,4-dimethoxylphenetyl)-2,2-dimethyl-6-pentyl-1,3-dioxane 
• 1360109-94-9 (3R,5S)-1-(3,4-dimethoxyphenyl)decane-3,5-diol 
• 39886-76-5 [6]-gingerol 
• 863780-90-9 (3R,5S)-1-(3,4-dimethoxyphenyl)decane-3,5-diyl diacetate 
• 39886-85-6 (3S,5S)-3,5-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)decane 
• 154905-69-8 (3R,5S)-1-(4-hydroxy-3-methoxyphenyl)decane-3,5-diol 
• 53254-51-6 (3R,5S)-1-(4-hydroxy-3-methoxyphenyl)decane-3,5-diyl diacetate 

Relevant articles and documents

An Efficient Enantioselective Synthesis of Natural Gingerols, the Active Principles of Ginger

A straightforward synthesis of (S)-gingerols 1-3 has been described. The requisite stereogenic center in the target molecules was introduced by Sharpless asymmetric dihydroxylation using a chiral complex, AD-mix β. This route is simple and efficient to prepare the products in very good yields.

Synthesis of gingerol and diarylheptanoids

The synthesis of gingerol 1 and related compounds 2-5 along with diarylheptanoids 6-8 has been accomplished using a Keck allylation, Crimmins' aldol reaction, aldehyde coupling with acetylene, and chelation controlled reductions as the key reactions. The absolute configuration of these molecules was confirmed by preparing their acetonide derivatives and by comparison of the NMR data with natural compounds.